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The compounds were designed through electronic, hydrophobic and steric modifications using the chemical structure of <jats:italic>N<\/jats:italic>\u2010{4\u2010[(2\u2010hydroxy\u20103\u2010methoxy\u20105\u2010propylphenyl)sulfamoyl]phenyl}acetamide (referred to as compound <jats:bold>7<\/jats:bold>) as a starting point to then assess a structure\u2010activity relationship (SAR) study. From the data generated, we observed that compounds <jats:bold>9<\/jats:bold>, <jats:bold>10<\/jats:bold> and <jats:bold>11<\/jats:bold> (which have modifications in the substituents of the aryl sulfonamide), efficiently reduced the cell viability of MCF\u20107 and MDA\u2010MB\u2010231 cell cultures. Based on initial data, we selected compounds <jats:bold>10<\/jats:bold> and <jats:bold>11<\/jats:bold> for further investigations into their antiproliferative and\/or cytotoxic profile against MDA\u2010MB\u2010231 cells, and we noted that compound <jats:bold>10<\/jats:bold> was the most promising compound in the series. Compound <jats:bold>10<\/jats:bold> promoted morphological changes and altered the dynamics of cell cycle progression in MDA\u2010MB\u2010231 cells, inducing arrest in G1\/S transition. Taken together, these results show that the dihydroeugenol\u2010aryl\u2010sulfonamide hybrid compound <jats:bold>10<\/jats:bold> (which has an electron withdrawing nitro group) displays promising antiproliferative activity against MDA\u2010MB\u2010231 cell lines.<\/jats:p>","DOI":"10.1002\/cbdv.202200831","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T14:59:56Z","timestamp":1666969196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and Structure\u2010Activity Relationship Studies of Novel Aryl Sulfonamides and Their Activity against Human Breast Cancer Cell Lines"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0611-5197","authenticated-orcid":false,"given":"Helloana","family":"Azevedo\u2010Barbosa","sequence":"first","affiliation":[{"name":"LQFar \u2013 Laboratory of Pharmaceutical Chemistry Research Faculty of Pharmaceutical Sciences Federal University of Alfenas  700, Gabriel Monteiro da Silva 37130-001 Alfenas, MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-2198","authenticated-orcid":false,"given":"Guilherme \u00c1lvaro","family":"Ferreira\u2010Silva","sequence":"additional","affiliation":[{"name":"LABAInt \u2013 Laboratory of Integrative Animal Biology Institute of Biomedical Sciences Federal University of Alfenas  Alfenas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Pereira","family":"do Vale","sequence":"additional","affiliation":[{"name":"LQFar \u2013 Laboratory of Pharmaceutical Chemistry Research Faculty of Pharmaceutical Sciences Federal University of Alfenas  700, Gabriel Monteiro da Silva 37130-001 Alfenas, MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3343-1854","authenticated-orcid":false,"given":"Jamie Anthony","family":"Hawkes","sequence":"additional","affiliation":[{"name":"LQFar \u2013 Laboratory of Pharmaceutical Chemistry Research Faculty of Pharmaceutical Sciences Federal University of Alfenas  700, Gabriel Monteiro da Silva 37130-001 Alfenas, MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8796-1426","authenticated-orcid":false,"given":"Marisa","family":"Ionta","sequence":"additional","affiliation":[{"name":"LABAInt \u2013 Laboratory of Integrative Animal Biology Institute of Biomedical Sciences Federal University of Alfenas  Alfenas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6362-2822","authenticated-orcid":false,"given":"Diogo Teixeira","family":"Carvalho","sequence":"additional","affiliation":[{"name":"LQFar \u2013 Laboratory of Pharmaceutical Chemistry Research Faculty of Pharmaceutical Sciences Federal University of Alfenas  700, Gabriel Monteiro da Silva 37130-001 Alfenas, MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc723"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.07.057"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00114-z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/392674"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2017.1314513"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2010.0197"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2017.1295225"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-013-0669-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12504"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2015.04.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12625"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5207439"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13318"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13362"},{"key":"e_1_2_8_16_1","first-page":"1425","article-title":"\u2018Synthesis and biological evaluation of new eugenol-derived 1,2,3-triazoles as antimycobacterial agents\u2019","volume":"30","author":"Dos Santos T.","year":"2019","journal-title":"J. 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