{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:09:04Z","timestamp":1790028544005,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20204BCJL23047"],"award-info":[{"award-number":["20204BCJL23047"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760705"],"award-info":[{"award-number":["81760705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Semiliquidambar cathayensis<\/jats:italic> Chang roots (SC) are traditional Chinese medicine for treating rheumatoid arthritis (RA). However, the effect and potential mechanism of SC remain unclear. This study aims to reveal the anti\u2010RA constituents and mechanisms of SC based on network pharmacology, molecular docking, and adjuvant\u2010induced arthritis (AIA) model rat experiment. In this work, 9\u2005potential active constituents, including kaempferol, quercetin, naringenin, paeoniflorin, catechin, fraxin, gentianin, hesperetin, and ellagic acid 3,3\u2032,4\u2010trimethyl ether, in SC crossed 65 target genes of RA. In addition, 28 core targets were enriched in inflammation and others, among which interleukin\u201017 (IL\u201017) and tumor necrosis factor (TNF) were the major targets. The binding of bio\u2010constituents with IL\u201017 and TNF were performed using molecular docking. Rat experiment demonstrated that the extract of SC restored body weight loss, reduced arthritis score and the indices of thymus and spleen, alleviated ankle joint histopathology, decreased the levels of rheumatoid factor (RF), C\u2010reactive protein (CRP), IL\u201017, TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, cyclooxygenase\u20102 (COX\u20102), 5\u2010lipoxygenase (5\u2010LOX), and matrix metalloproteinase\u20102 (MMP\u20102), whereas elevated the levels of IL\u20104 and IL\u201010. Collectively, it was the first time to comprehensively reveal the anti\u2010RA efficacy and mechanism of SC <jats:italic>via<\/jats:italic> suppressing the inflammatory pathway based on network pharmacology, molecular docking, and experimental verification, which provide chemical and pharmacological evidences for the clinical application of SC.<\/jats:p>","DOI":"10.1002\/cbdv.202200916","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T03:50:32Z","timestamp":1669348232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Revealing the Active Constituents and Mechanisms of <i>Semiliquidambar cathayensis<\/i> Chang Roots against Rheumatoid Arthritis through Network Pharmacology, Molecular Docking, and <i>in Vivo<\/i> Experiment"],"prefix":"10.1002","volume":"20","author":[{"given":"Xiaoyi","family":"Xia","sequence":"first","affiliation":[{"name":"Jiangxi University of Chinese Medicine  Nanchang 330004 P. 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