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During the two\u2010month CCl<jats:sub>4<\/jats:sub> exposure of Wistar rats, propolis extract (PE) and royal jelly (RJ) were added in order to test the potential protective effect against hepato\u2010renal injury. Ketonuria, proteinuria, high creatinine and urea levels are the result of CCl<jats:sub>4<\/jats:sub>\u2010induced nephrotoxicity. Severe disorders of hematological indicators indicate anemia; high values of leukocytes indicate inflammatory condition. Cytogenetic impairments in hepatocytes, aggregation of platelets, and hypoproteinemia indicate severe liver impairment. Results suggest a more significant protective role of RJ compared to PE. Both extracts regulated proteinuria, ketonuria, hypoproteinemia and reduced platelet aggregation in the hepatic circulation. The increase in the number of erythrocytes (RBC) suggest protective effects against anemia; the decrease in the number of leukocytes can be linked to anti\u2010inflammatory effects. PE and RJ have a beneficial effect against hepato\u2010renal injury, anemia and anti\u2010inflammatory conditions caused by CCl<jats:sub>4<\/jats:sub>.<\/jats:p>","DOI":"10.1002\/cbdv.202200948","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T08:35:34Z","timestamp":1669192534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ameliorative Effects of Propolis and Royal Jelly against CCl<sub>4<\/sub>\u2010Induced Hepatotoxicity and Nephrotoxicity in Wistar Rats"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1281-1527","authenticated-orcid":false,"given":"Muhamed","family":"Focak","sequence":"first","affiliation":[{"name":"Department of Biology University of Sarajevo-Faculty of Science  Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damir","family":"Suljevic","sequence":"additional","affiliation":[{"name":"Department of Biology University of Sarajevo-Faculty of Science  Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.41.561"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.06.016"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711427055"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2020-0048"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1136"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-11-48"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00255-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062363"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-78"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-001-1178-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1081\/LESB-200030880"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.15283\/ijsc.2012.5.1.57"},{"key":"e_1_2_9_13_1","first-page":"145","article-title":"\u2018Hepatoprotective efficacy of propolis extract: A biochemical and histopathological approach\u2019","volume":"6","author":"Bhadauria M.","year":"2007","journal-title":"Iran. 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