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This study aimed to synthesize 15 isothiocyanates derived from \u03b2\u2010citronellol and evaluate their antifouling activities and toxicities against cypris larvae of the barnacle <jats:italic>Amphibalanus amphitrite<\/jats:italic>. The synthesized isothiocyanates exhibited effective antifouling activities (EC<jats:sub>50<\/jats:sub>=0.10\u20133.33 \u03bcg mL<jats:sup>\u22121<\/jats:sup>) with high therapeutic ratios (LC<jats:sub>50<\/jats:sub>\/EC<jats:sub>50<\/jats:sub> &gt;30). Four isothiocyanates with an amide or isocyano group showed great potential as effective antifouling agents (EC<jats:sub>50<\/jats:sub>=0.10\u20130.32 \u03bcg mL<jats:sup>\u22121<\/jats:sup>, LC<jats:sub>50<\/jats:sub>\/EC<jats:sub>50<\/jats:sub>=104\u2013833). The enantiomers of the isothiocyanates only slightly differed in their antifouling activities. These results may serve as a basis for further research and development of \u03b2\u2010citronellol\u2010derived isothiocyanates as effective low\u2010toxic antifouling agents. To the best of our knowledge, this study is the first to report the antifouling activities of isothiocyanates derived from accessible natural products.<\/jats:p>","DOI":"10.1002\/cbdv.202200953","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T03:02:45Z","timestamp":1672023765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anti\u2010Barnacle Activities of Isothiocyanates Derived from \u03b2\u2010Citronellol and Their Structure\u2013Activity Relationships"],"prefix":"10.1002","volume":"20","author":[{"given":"Aina","family":"Tanikawa","sequence":"first","affiliation":[{"name":"Laboratory of Bio-organic Chemistry Tokyo University of Agriculture and Technology  3-5-8 Saiwai-cho Fuchu-shi Tokyo 183-8509 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaya","family":"Fujihara","sequence":"additional","affiliation":[{"name":"Laboratory of Bio-organic 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