{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:23:21Z","timestamp":1783409001220,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160655"],"award-info":[{"award-number":["32160655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plant diseases can seriously affect the growth of food crops and economic crops. To date, pesticides are still among the most effective methods to prevent and control plant diseases worldwide. Consequently, to develop potential pesticide molecules, a series of novel 2\u2010phenylglycine derivatives containing 1,3,4\u2010oxadiazole\u20102\u2010thioethers were designed and synthesized. The bioassay results revealed that <jats:bold>G<jats:sub>19<\/jats:sub><\/jats:bold> exhibited great <jats:italic>in\u2005vitro<\/jats:italic> antifungal activity against <jats:italic>Thanatephorus cucumeris<\/jats:italic> with an EC<jats:sub>50<\/jats:sub> value of 32.4\u2005\u03bcg\/mL, and <jats:italic>in\u2005vivo<\/jats:italic> antifungal activity against <jats:italic>T. cucumeris<\/jats:italic> on rice leaves at a concentration of 200.0\u2005\u03bcg\/mL (66.9\u2009%) which was close that of azoxystrobin (73.2\u2009%). Compounds <jats:bold>G<jats:sub>24<\/jats:sub><\/jats:bold> (80.2\u2009%), <jats:bold>G<jats:sub>25<\/jats:sub><\/jats:bold> (89.4\u2009%), and <jats:bold>G<jats:sub>27<\/jats:sub><\/jats:bold> (83.3\u2009%) exhibited impressive <jats:italic>in\u2005vivo<\/jats:italic> inactivation activity against <jats:italic>tobacco mosaic virus<\/jats:italic> (<jats:italic>TMV<\/jats:italic>) at a concentration of 500.0\u2005\u03bcg\/mL, which was comparable to that of ningnanmycin (96.3\u2009%) and markedly higher than that of ribavirin (55.6\u2009%). The antibacterial activity of <jats:bold>G<jats:sub>16<\/jats:sub><\/jats:bold> (63.1\u2009%), <jats:bold>G<jats:sub>26<\/jats:sub><\/jats:bold> (89.9\u2009%), <jats:bold>G<jats:sub>27<\/jats:sub><\/jats:bold> (78.0\u2009%), and <jats:bold>G<jats:sub>28<\/jats:sub><\/jats:bold> (68.0\u2009%) against <jats:italic>Xoo<\/jats:italic> at a concentration of 50.0\u2005\u03bcg\/mL was higher than that of thiadiazole copper (18.0\u2009%) and bismerthiazol (38.9\u2009%). Preliminary mechanism studies on the antifungal activity against <jats:italic>T. cucumeris<\/jats:italic> demonstrated that <jats:bold>G<jats:sub>19<\/jats:sub><\/jats:bold> can affect the growth of mycelia by disrupting the integrity of the cell membrane and altering the permeability of the cell. These studies revealed that the amino acid derivatives containing a 1,3,4\u2010oxadiazole moiety exhibited certain antifungal, antibacterial, and anti\u2010TMV activities, and these derivatives can be further modified and developed as potential pesticide molecules.<\/jats:p>","DOI":"10.1002\/cbdv.202200957","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T14:57:55Z","timestamp":1671029875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design, Synthesis and Bioassay of 2\u2010Phenylglycine Derivatives as Potential Pesticide Candidates"],"prefix":"10.1002","volume":"20","author":[{"given":"Hong","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R &amp; D of Fine Chemicals of Guizhou University  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailong","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R &amp; D of Fine Chemicals of Guizhou University  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanlin","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R &amp; D of Fine Chemicals of Guizhou University  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocui","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R &amp; D of Fine Chemicals of Guizhou University  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang Guizhou 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-9725","authenticated-orcid":false,"given":"Zhibing","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R &amp; 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