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From a dichloromethane extract were obtained five different fractions called F1 to F5, and sub\u2010fractions F4\u20101, F5\u20101, F5\u20102, and F5\u20103; and were evaluated as anti\u2010neuroinflammatory, antioxidant, and nootropic agents in mice exposed to lipopolysaccharide. Also, were isolated herniarin, daphnoretin, and fraction's terpenes with an anti\u2010inflammatory activity using 12\u2010O\u2010tetradecanoylphorbol\u201013\u2010acetate\u2010induced auricular edema. The inhibition of local edema was: F1 (73.6\u2009%), F2 (57\u2009%), F3 (62.61\u2009%), F4 (87.3\u2009%), and F5 (93.57\u2009%). Terpene fraction inhibited at 89.60\u2009%, herniarin at 86.92\u2009% (Emax 99.01\u2009%, ED50 0.35\u2005mg\u2009ear<jats:sup>\u22121<\/jats:sup>), and daphnoretin at 86.41\u2009%. Fractions F4\u20101 and F5\u20102 (10\u2005mg\u2009kg<jats:sup>\u22121<\/jats:sup>) enhancer spatial memory acquisition and spontaneous motor activity; reduced IL\u20101\u03b2, TNF\u2010\u03b1, and IL\u20106; increased IL\u201010, enhanced the activity of CAT and GR. <jats:italic>D. buccinatoria<\/jats:italic> has neuroprotective activity and contains daphnoretin and herniarin, with anti\u2010inflammatory activity.<\/jats:p>","DOI":"10.1002\/cbdv.202200969","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T02:04:20Z","timestamp":1679969060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Anti\u2010Inflammatory and Neuroprotective Effects of Standardized Fractions in Herniarin and Daphnoretin from <i>Distictis buccinatoria<\/i>"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-4258","authenticated-orcid":false,"given":"Sandra","family":"Liliana Porras\u2010D\u00e1vila","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica del Sur Instituto Mexicano del Seguro Social  Argentina #1, Col. 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