{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:33:14Z","timestamp":1773952394061,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074280"],"award-info":[{"award-number":["82074280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the processing field, there is a saying that \u201cseed drugs be stir\u2010fried\u201d. Bitter almond (BA) is a kind of seed Chinese medicine. BA need be used after being fried. To distinguish raw bitter almonds (RBA) from processed products and prove the rationality of \u201cseed drugs be stir\u2010fried\u201d, we analyzed the RBA and five processed products (scalded bitter almonds, fried bitter almonds, honey fried bitter almonds, bran fried bitter almonds, bitter almonds cream) using RP\u2010HPLC fingerprints and chemometric methods. The similarity between RBA and processed products was 0.733\u223c0.995. Hierarchically clustered heatmap was used to evaluate the changes in components. Principal component analysis (PCA) was used for classification, and all samples are distinguished according to RBA and five processing methods. Six chemical markers were obtained by partial least squares discriminant analysis (PLS\u2010DA). The content and degradation rate of amygdalin and \u03b2\u2010glucosidase activity were determined. Compared with RBA, the content and degradation rate of amygdalin, and \u03b2\u2010glucosidase activity were increased in bitter almonds cream. The content and degradation rate were decreased, and \u03b2\u2010glucosidase was inactivated in other processed products. The above results showed that stir\u2010frying had the best effect. The results showed that processing can ensure the stability of RBA quality, and the saying \u201cseed drugs be stir\u2010fried\u201d is reasonable.<\/jats:p>","DOI":"10.1002\/cbdv.202200989","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T05:59:27Z","timestamp":1675749567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Bitter Almonds and Processed Products Based on HPLC\u2010Fingerprints and Chemometry"],"prefix":"10.1002","volume":"20","author":[{"given":"Guoqin","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"},{"name":"State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zicheng","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4246-7883","authenticated-orcid":false,"given":"Xiaoliang","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin 301617 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"e_1_2_10_1_1","first-page":"2227","article-title":"\u2018Traditional understanding and modern research progress on theory of \u2018seed drugs be stir-fried\u2019\u2019","volume":"53","author":"Shi Y.","year":"2022","journal-title":"China Tradit Herbal Drugs."},{"key":"e_1_2_10_2_1","first-page":"240","article-title":"\u2018Study on the chemical difference between raw semen strychni and frying semen strychni based on plant metabolomics\u2019","volume":"31","author":"Qin W. 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