{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:34:18Z","timestamp":1792694058271,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32060627"],"award-info":[{"award-number":["32060627"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22207021"],"award-info":[{"award-number":["22207021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to find novel antiplatelet drugs for the treatment of ischemic stroke, a series of 3\u2010butylphthalide derivatives containing isopentenylphenol moiety were designed, synthesized and characterized with spectroscopic analyses. The <jats:italic>in\u2005vitro<\/jats:italic> antiplatelet activity results indicated that compound <jats:bold>3<\/jats:bold> better inhibited the arachidonic acid (AA) induced platelet aggregation than aspirin (ASP) and 3\u2010butylphthalide (NBP). Additionally, compared with precursor NBP, compound\u2005<jats:bold>3<\/jats:bold> possessed outstanding antithrombotic activity in the animal experiment model, which could effectively alleviate the formation of tail thrombus and carotid artery thrombus in mice. More importantly, intraperitoneal administration of compound\u2005<jats:bold>3<\/jats:bold> can well protected the rats against ischemia\/reperfusion\u2010induced brain injury. Further pharmacokinetic (PK) assay indicated that compound\u2005<jats:bold>3<\/jats:bold> had good absorption characteristics and metabolic stability <jats:italic>in\u2005vivo<\/jats:italic>. Overall, the present research provides a new candidate compound for the treatment of ischemic stroke caused by platelet aggregation.<\/jats:p>","DOI":"10.1002\/cbdv.202201002","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T03:34:22Z","timestamp":1669347262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis of Novel 3\u2010Butylphthalide Derivatives Containing Isopentenylphenol Moiety as Potential Antiplatelet Agents for the Treatment of Ischemic Stroke"],"prefix":"10.1002","volume":"20","author":[{"given":"Qinyang","family":"Yu","sequence":"first","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilan","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongfu","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhong","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5607-3813","authenticated-orcid":false,"given":"Lingling","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"GBD 2019 stroke collaborators \u2018Global regional and national burden of stroke and its risk factors 1990\u20132019: a systematic analysis for the global burden of disease study 2019\u2019 Lancet Neurol.2021 20 795\u2013820."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525822"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/10600280211073009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313155"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00887"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527317666180612125843"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X19500265"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2019.1681982"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.02.031"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.03.171"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm300681r"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.06.090"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)76141-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803414132"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.051"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.03.038"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.01.016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116184"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.06.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-951772"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000435"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.sp007185"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-009-0333-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(90)90106-M"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.07.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0554-2"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4625"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202201002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202201002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202201002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:18:37Z","timestamp":1692580717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202201002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/cbdv.202201002"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202201002","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]},"assertion":[{"value":"2022-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202201002"}}