{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:16:46Z","timestamp":1789139806336,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21977083"],"award-info":[{"award-number":["21977083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The discovery of new highly active molecules from natural products is a common method to create new pesticides. Celangulin V targeting <jats:italic>Mythimna separate<\/jats:italic> (<jats:italic>M. separate<\/jats:italic>) midgut V\u2010ATPase\u2005 H subunit, has received considerable attention for its excellent insecticidal activity and unique mechanism of action. Therefore, combined with our preliminary work, thirty\u2010seven sulfonamide derivatives bearing propargyloxy or pyridine groups were systematically synthesized to search for insecticidal candidate compounds with low cost and high efficiency on the\u2005 H subunit of V\u2010ATPase. Bioactive results showed that compounds <jats:bold>A2\u2010A4<\/jats:bold> and <jats:bold>A6\u2010A7<\/jats:bold> exhibited a better bioactivity with median effective concentration (LC<jats:sub>50<\/jats:sub>) values (2.78, 3.11, 3.34, 3.54 and 2.48\u2005mg\/mL, respectively) against third\u2010instar larvae of <jats:italic>M. separate<\/jats:italic> than Celangulin V (LC<jats:sub>50<\/jats:sub>=18.1\u2005mg\/mL). Additionally, molecular docking experiments indicated that these molecules may act on the\u2005H subunit of V\u2010ATPase. Based on the above results, these compounds provide new ideas for the discovery of insecticides.<\/jats:p>","DOI":"10.1002\/cbdv.202201020","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T04:11:30Z","timestamp":1671509490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Design, Synthesis, Insecticidal Activities and Molecular Docking of Sulfonamide Derivatives Containing Propargyloxy or Pyridine Groups"],"prefix":"10.1002","volume":"20","author":[{"given":"Jian\u2010Jun","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University, Xian Yang Shi  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University, Xian Yang Shi  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University, Xian Yang Shi  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Qian","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University, Xian Yang Shi  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University, Xian Yang Shi  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Yin","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University, Xian Yang Shi  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Botanical Pesticide R&amp;D in Shaanxi Province  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6613-4077","authenticated-orcid":false,"given":"Ji\u2010Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University, Xian Yang Shi  Yangling 712100 China"},{"name":"Key Laboratory of Botanical Pesticide R&amp;D in Shaanxi Province  Yangling 712100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c05584"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200916741"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf4045843"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.12.040"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2015.10.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf405512e"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf405316w"},{"key":"e_1_2_9_8_1","first-page":"551","article-title":"\u2018Synthesis, Crystal Structure and Insecticidal Activity of N-(pyridin-2-ylmethyl)-1-phenyl-1,4,5,6,7,8-hexahydrocyclohepta cpyrazole-3-carboxamide\u2019","volume":"37","author":"Deng X. 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