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The optimal extraction conditions were determined as an extraction temperature of 150\u2009\u00b0C, an extraction time of 40\u2005min, and a liquid\u2010solid ratio of 35\u2009:\u20091\u2005mL\/g. The total phenolic content reached 21.35\u2005mg gallic acid \/g, which was 16\u2009% higher than that by hot water extraction. The subcritical water extraction extract exhibited strong scavenging activity of DPPH free radical and ABTS<jats:sup>+<\/jats:sup> free radical, as well as significant tyrosinase inhibitory activity. The study suggests that subcritical water extraction can alter the composition of the extracts, leading to the production of various phenolic compounds, effective antioxidants, and tyrosinase inhibitors from <jats:italic>Vaccinium dulciana<\/jats:italic> Wight leaves. These findings confirm the potential of <jats:italic>Vaccinium dunalianum<\/jats:italic> Wight as a natural antioxidant molecule source for the medicine and food industries, and for the therapy of skin pigmentation disorders.<\/jats:p>","DOI":"10.1002\/cbdv.202201099","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T13:17:06Z","timestamp":1682428626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Subcritical Water Extraction of Phenolic Compounds from <i>Vaccinium Dunalianum<\/i> Wight Leaves and Their Antioxidant and Tyrosinase Inhibitory Activities <i>in Vitro<\/i>"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-2017","authenticated-orcid":false,"given":"Xiaoqin","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of National Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry 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