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Some compounds exhibited selective cytotoxicity against U87\u2010MG cancer cell lines in\u2005vitro, in which compound <jats:bold>C4<\/jats:bold> were found to have the best antiproliferative activity. SAR study indicated 1,2,3\u2010triazole group may be crucial for enhancing compounds\u2019 cytotoxicity. <jats:bold>C4<\/jats:bold> was verified to induce ferroptosis in U87\u2010MG cells by transcription, lipid peroxidation, lipid ROS assays. Furthermore, <jats:bold>C4<\/jats:bold> was up\u2010regulated LC3\u2010II, degradated FTH1, and then increasing iron resulted in the down\u2010regulation of NCOA4. Together, all above evidences highlighted the potential of compound <jats:bold>C4<\/jats:bold> that triggered ferroptosis by activating ferritinophagy against U87\u2010MG cells.<\/jats:p>","DOI":"10.1002\/cbdv.202201117","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T06:05:45Z","timestamp":1671516345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel Chalcone\u2010Phenazine Hybrids Induced Ferroptosis in U87\u2010MG Cells through Activating Ferritinophagy"],"prefix":"10.1002","volume":"20","author":[{"given":"Chunhua","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Engineering China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qifan","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuolu","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Engineering China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-6884","authenticated-orcid":false,"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Engineering China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology China Pharmaceutical University  Nanjing 210009 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00462-0"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26954"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13148"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2479"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21698"},{"key":"e_1_2_9_7_1","first-page":"3146","article-title":"\u2018Curr. 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