{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:54:27Z","timestamp":1790589267731,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Geographic conditions (altitude, climate, and local flora) lead to significant differences in the chemical composition of propolis. Therefore, more research is needed for propolis in different geographical regions. So, the aim of this study was to evaluate the phenolic profile, total phenolic content, antioxidant, and antidiabetic properties of\n                    <jats:italic>P\u00fcl\u00fcm\u00fcr propolis<\/jats:italic>\n                    from Turkey. Methanol (MeOH), chloroform (CHCl\n                    <jats:sub>3<\/jats:sub>\n                    ), and hexane extracts of propolis were analyzed. LC\u2010ESI\u2010MS\/MS analysis of the extracts showed that the most abundant phenolic compound is caffeic acid in the MeOH extract (2943.12\u00b111.12\u2005\u03bcg phenolics\/g extract), while on the other hand, CHCl\n                    <jats:sub>3<\/jats:sub>\n                    extract had the highest total phenolic content (125.75\u00b11.02\u2005mg GAE\/g extract). Antioxidant activity was measured using ABTS and DPPH assays, whereas CHCl\n                    <jats:sub>3<\/jats:sub>\n                    extract (IC\n                    <jats:sub>50<\/jats:sub>\n                    =6.35\u00b10.11 and 28.84\u00b10.10\u2005\u03bcg\/mL, respectively) and MeOH extracts (IC\n                    <jats:sub>50<\/jats:sub>\n                    =5.04\u00b10.07 and 28.80\u00b10.09\u2005\u03bcg\/mL, respectively) showed relatively high antioxidant activity. The MeOH extract showed better antidiabetic activity than the standard compound, acarbose (IC\n                    <jats:sub>50<\/jats:sub>\n                    =0.544 and 0.805\u2005mg\/mL, respectively).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202201189","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T07:40:09Z","timestamp":1679989209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["LC\u2010ESI\u2010MS\/MS Chemical Characterization, Antioxidant and Antidiabetic Properties of Propolis Extracted with Organic Solvents from Eastern Anatolia Region"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-950X","authenticated-orcid":false,"given":"Tugrul","family":"Cagri Akman","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy Erzincan Binali Yildirim University  25240 Erzincan Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-3425","authenticated-orcid":false,"given":"Samed","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques \u00c7ay\u0131rl\u0131 Vocational School Erzincan Binali Yildirim University  24500 Erzincan Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4091-9033","authenticated-orcid":false,"given":"\u00d6mer","family":"Kayir","sequence":"additional","affiliation":[{"name":"Scientific, Technical, Application and Research Center Hitit University  19030 \u00c7orum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0349-0223","authenticated-orcid":false,"given":"Zeynep","family":"Aksit","sequence":"additional","affiliation":[{"name":"Department of Hotel, Restaurant and Service, Tourism and Hospitality Vocational School Erzincan Binali Yildirim University  25240 Erzincan Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1509-851X","authenticated-orcid":false,"given":"H\u00fcseyin","family":"Aksit","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy Erzincan Binali Yildirim University  25240 Erzincan Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-1344","authenticated-orcid":false,"given":"Nusret","family":"Genc","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Art and Science Gaziosmanpasa University  60240 Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(97)00145-2"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfca.2021.104234"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1051\/apido:2000102"},{"key":"e_1_2_9_4_1","first-page":"1","article-title":"\u2018Propolis: an update on its chemistry and pharmacological applications\u2019","volume":"171","author":"Hossain R.","year":"2022","journal-title":"Chin. 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