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In 1965, Barnett Rosenberg serendipitously discovered the metal\u2010based compound cisplatin, an outstanding breakthrough in the history of metal\u2010based anticancer complexes and led to a new area of anticancer drug discovery. Many metal\u2010based compounds have been studied for their potential anticancer properties. Some of these compounds have FDA approval for clinical use, while others are now undergoing clinical trials for cancer therapy and detection. In the present study, we have highlighted the primary mode of action of metallic complexes and all FDA\u2010approved\/under clinical trial drugs with reference to cancer treatment. This review also focuses on recent progress on metal\u2010based complexes such as platinum, ruthenium, iron, <jats:italic>etc<\/jats:italic>. with potential anticancer activities.<\/jats:p>","DOI":"10.1002\/cbdv.202300061","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T06:56:01Z","timestamp":1677221761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Metal Complexes in Cancer Treatment: Journey So Far"],"prefix":"10.1002","volume":"20","author":[{"given":"Ankit","family":"Kumar Singh","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab  Ghudda Bathinda, 151401 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adarsh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab  Ghudda Bathinda, 151401 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshwardhan","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab  Ghudda Bathinda, 151401 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Sonawane","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab  Ghudda Bathinda, 151401 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek","family":"Pathak","sequence":"additional","affiliation":[{"name":"Laboratory of Computational Modeling of Drugs Higher Medical and Biological School South Ural State University  Chelyabinsk 454008 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grishina","sequence":"additional","affiliation":[{"name":"Laboratory of Computational Modeling of Drugs Higher Medical and Biological School South Ural State University  Chelyabinsk 454008 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagat","family":"Pal Yadav","sequence":"additional","affiliation":[{"name":"Bioorganic and Medicinal Chemistry Research Laboratory Department of Pharmaceutical Sciences Sam Higginbottom University of Agriculture, Technology and Sciences  Prayagraj 211007 India"},{"name":"Pharmacology research Laboratory Faculty of Pharmaceutical Sciences Rama University  Kanpur 209217 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Verma","sequence":"additional","affiliation":[{"name":"Bioorganic and Medicinal Chemistry Research Laboratory Department of Pharmaceutical Sciences Sam Higginbottom University of Agriculture, Technology and Sciences  Prayagraj 211007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-2826","authenticated-orcid":false,"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab  Ghudda Bathinda, 151401 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"106","article-title":"\u2018In Metal-Based Chemotherapy Drugs\u2019","volume":"99","author":"Kasemodel K.","year":"2019","journal-title":"Proc. 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