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(AM) is a Chinese herbal medicine that is widely used for treating gastrointestinal diseases. However, little research has focused on it as a single medicine for treating gastric ulcers. Honey\u2010bran stir\u2010frying is a characteristic method of concocting AM, so we speculated that AM is more effective after this preparation process. Analysis by ultra\u2010high\u2010performance liquid chromatography\u2010hybrid quadrupole\u2010Orbitrap high\u2010resolution mass spectrometry revealed changes in the chemical composition of raw Atractylodes (SG), bran\u2010fried Atractylodes (FG), and honey\u2010bran\u2010fried Atractylodes (MFG). MFG was superior to SG and FG in improving the pathological structure of gastric tissue in rats with acute gastric ulcers, reducing inflammatory cell infiltration in gastric tissue, and significantly reducing malondialdehyde while increasing superoxide dismutase and glutathione peroxidase, and reducing the damage caused by free radical accumulation in the gastric mucosa. In addition, MFG reduced the expression of matrix metalloproteinase\u20109 (MMP\u20109), an inhibitor of metalloproteinase\u20101 (TIMP\u20101) and nuclear factor kappa\u2010B (NF\u2010\u03baB)proteins, inhibited inflammatory response, and regulated the degradation and rebalancing of the extracellular matrix. Fecal microbiota analysis also revealed that MFG normalized the intestinal flora to some extent. Our study shows that AM had a protective effect on rats with alcohol\u2010induced acute gastric ulcers before and after processing, and AM\u2010processed products were more effective than raw ones. Compared with MF, MFG had a higher rate of ulcer inhibition and a stronger anti\u2010inflammatory effect, and its mechanism of action was related to the NF\u2010\u03baB\u2010MMP\u20109\/TIMP\u20101 signaling pathway.<\/jats:p>","DOI":"10.1002\/cbdv.202300068","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T12:38:45Z","timestamp":1682599125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Atractylodes Processing Products Protect against Gastric Ulcers in Rats by Influencing the NF\u2010\u03baB\u2010MMP\u20109\/TIMP\u20101 Regulatory Mechanism and Intestinal Flora"],"prefix":"10.1002","volume":"20","author":[{"given":"Linlin","family":"Zeng","sequence":"first","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaomei","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Hong","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3307-6031","authenticated-orcid":false,"given":"Jun","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.37.4.3894"},{"key":"e_1_2_10_2_1","first-page":"765","volume":"68","author":"Kolgazi M.","year":"2017","journal-title":"J. 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