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This interaction can also cause side effects by binding to host lanosterol\u201014\u03b1\u2010demethylase. Hence, it is necessary to design, synthesize and test new antifungal agents that have different structures than those of azoles and other antifungal drugs of choice in clinical practice. Consequently, a series of steroidal 1,4\u2010dihydropyridine analogs <jats:bold>16<\/jats:bold>\u2013<jats:bold>21<\/jats:bold> were synthesized and screened for their <jats:italic>in\u2005vitro<\/jats:italic> anti\u2010fungal activity against three <jats:italic>Candida<\/jats:italic> species as steroids\u2010based medications have low toxicity, less vulnerability to multi\u2010drug resistance, and high bioavailability by being capable of penetrating the cell wall and binding to specific receptors. Initially, Claisen\u2013Schmidt condensation takes place between steroidal ketone (dehydroepiandrosterone) and an aromatic aldehyde forming steroidal benzylidene <jats:bold>8<\/jats:bold>\u2013<jats:bold>13<\/jats:bold> followed by Hantzsch 1,4\u2010dihydropyridine synthesis resulting in steroidal 1,4\u2010dihydropyridine derivatives <jats:bold>16<\/jats:bold>\u2013<jats:bold>21<\/jats:bold>. The results exhibited that compound <jats:bold>17<\/jats:bold> has significant anti\u2010fungal potential with an MIC value of 750\u2005\u03bcg\/ml for <jats:italic>C.\u2005albicans<\/jats:italic> and <jats:italic>C.\u2005glabrata<\/jats:italic> and 800\u2005\u03bcg\/ml for <jats:italic>C.\u2005tropicalis. In\u2005silico<\/jats:italic> molecular docking and ADMET studies were also performed for compounds <jats:bold>16<\/jats:bold>\u2013<jats:bold>21<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/cbdv.202300096","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T10:35:38Z","timestamp":1681295738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis, Anti\u2010Fungal Potency and <i>In silico<\/i> Studies of Novel Steroidal 1,4\u2010Dihydropyridines"],"prefix":"10.1002","volume":"20","author":[{"given":"Asna","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Chemistry Aligarh Muslim University  Aligarh 202002, UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arfeen","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aligarh Muslim University  Aligarh 202002, UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiema","family":"Ahmedi","sequence":"additional","affiliation":[{"name":"Department of Biosciences Jamia Millia Islamia  New Delhi 110025 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhat","family":"Manzoor","sequence":"additional","affiliation":[{"name":"Department of Biosciences Jamia Millia Islamia  New Delhi 110025 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4984-0495","authenticated-orcid":false,"given":"Tabassum","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aligarh Muslim University  Aligarh 202002, UP India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2018.04.003"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2016.03.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2021.108827"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600551213"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-006-0053-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.03.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2002.tb11448.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(07)70840-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2012.09.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2012.10.017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcata.2010.11.012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2009.01.140"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.18822150102"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(03)00813-X"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)00660-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2006.12.074"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2006.05.037"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2004.11.079"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12154-014-0121-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/204237"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.22913"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01575120"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2021.132086"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.07.067"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2012.04.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2017.06.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA11049A"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.02.015"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202202286"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2022.109154"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2023.109186"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2010.10.146"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2012.02.001"},{"key":"e_1_2_9_34_1","first-page":"1","volume":"4","author":"Athar M.","year":"2019","journal-title":"Phys. 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