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This study included rats with gastric ulcers induced by applying serosal glacial acetic acid. These rats were then given either saline (vehicle) or PLC at doses of 60 and 120\u2005mg\/kg, administered orally 3\u2005days after ulcer induction for 14 consecutive days. Our study found that treatment with PLC resulted in a reduction of the gastric ulcer area, a faster rate of ulcer healing, and stimulated mucosal restoration. Additionally, the treatment with PLC reduced the number of Iba\u20101+ M1 macrophages while increasing the number of galectin\u20103+ M2 macrophages, as well as desmin+ microvessels, and \u03b1\u2010SMA+ myofibroblasts in the gastric ulcer bed. The mRNA expression of <jats:italic>COX\u20102<\/jats:italic>, <jats:italic>eNOS<\/jats:italic>, <jats:italic>TGF\u2010\u03b21<\/jats:italic>, <jats:italic>VEGFA<\/jats:italic>, and <jats:italic>EGF<\/jats:italic> in the ulcerated gastric mucosa was greater in the PLC\u2010treated groups compared with the vehicle\u2010treated rats. In conclusion, these findings suggest that PLC treatment may accelerate gastric ulcer healing by stimulating mucosal reconstruction, macrophage polarization, angiogenesis, and fibroblast proliferation, as well as fibroblast\u2010myofibroblast transition. This process is associated with the upregulation of <jats:italic>TGF\u2010\u03b21<\/jats:italic>, <jats:italic>VEGFA<\/jats:italic>, and <jats:italic>EGF<\/jats:italic>, as well as modulation of the cyclooxygenase\/nitric oxide synthase systems.<\/jats:p>","DOI":"10.1002\/cbdv.202300210","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T01:54:11Z","timestamp":1686275651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Acetic Acid\u2010Induced Chronic Gastric Ulcer Healing by Propionyl\u2010L\u2010Carnitine Administration"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5247-5222","authenticated-orcid":false,"given":"Emrah","family":"Ipek","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-7956","authenticated-orcid":false,"given":"Gamze Sevri","family":"Ekren A\u015f\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2641-2321","authenticated-orcid":false,"given":"Erkmen Tu\u011frul","family":"Epikmen","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7743-6265","authenticated-orcid":false,"given":"M\u00fcr\u00fcvvet","family":"Abbak","sequence":"additional","affiliation":[{"name":"Science Technology Research and Application Center Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1490-8832","authenticated-orcid":false,"given":"B\u00fc\u015fra Kibar","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4254-7146","authenticated-orcid":false,"given":"\u015eule Yurdag\u00fcl","family":"\u00d6zsoy","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-7485","authenticated-orcid":false,"given":"Recai","family":"Tunca","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"e_1_2_11_1_1","first-page":"9","volume":"220","author":"Tarnawski A.","year":"1995","journal-title":"Scand. 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