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The <jats:italic>in\u2005vitro<\/jats:italic> results established all the three compounds as potent tyrosinase inhibitors relative to the standard. The Kinetics mechanism plots established that compound <jats:bold>8<\/jats:bold> inhibited the enzyme non\u2010competitively. The inhibition constants <jats:italic>K<jats:sub>i<\/jats:sub><\/jats:italic> calculated from Dixon plots for this compound was 0.0025\u2005\u03bcM. Additionally, computational techniques were used to explore electronic structures of synthesized compounds. Fully optimized geometries were further docked with tyrosinase enzyme for inhibition studies. Reasonably good binding\/interaction energies and intermolecular interactions were obtained. Finally, drug likeness was also predicted using the rule of five (RO5) and Chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET) characteristics. It is anticipated that current experimental and computational investigations will evoke the scientific interest of the research community for the above\u2010entitled compounds.<\/jats:p>","DOI":"10.1002\/cbdv.202300257","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T13:25:06Z","timestamp":1692019506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and Computational Exploration of Morpholine Bearing Halogenated Sulfonamides as Potential Tyrosinase Inhibitors"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-9286","authenticated-orcid":false,"given":"Muhammad Athar","family":"Abbasi","sequence":"first","affiliation":[{"name":"Department of Chemistry Government College University  Lahore 54000 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3078-6660","authenticated-orcid":false,"given":"Hussain","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Natural Sciences Kongju National University  Gongju 32588 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Aziz\u2010ur\u2010Rehman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Government College University  Lahore 54000 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabahat Zahra","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Chemistry Government College University  Lahore 54000 Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabbir","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science King Khalid University, Abha  61413, P.O. 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