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The animals were divided into nine groups: control, negative control (ulcer), positive control (omeprazole), and experimental groups, which were summarized by 200, 400, and 600\u2005mg\/kg, bw for aqueous\u2010based and ethanol, respectively. According to the histopathological evaluation, more than others, the doses of 200 and 400\u2005mg\/kg of aqueous\u2010based propolis extracts had different degrees of positive effects on the gastric mucosa. Generally, the biochemical analyses of the gastric tissue showed a correlation with microscopic evaluations. According to the phenolic profile analysis, while pinocembrin (684.34\u00b11.70\u2005\u03bcg\/ml) and chrysin (540.54\u00b19.06\u2005\u03bcg\/ml) were the most abundant phenolics in the ethanolic extract, ferulic acid (53.77\u00b10.07\u2005\u03bcg\/ml) and <jats:italic>p\u2010<\/jats:italic>coumaric acid (52.61\u00b10.42\u2005\u03bcg\/ml) dominated the aqueous\u2010based extract. Also, the total phenolic content (TPC), total flavonoid content (TFC), and DPPH radical scavenging activity of the ethanolic extract showed almost nine\u2010fold superiority compared to the aqueous\u2010based extracts. Based on data from preclinical data, it was decided that the best doses for the main goal of the study were 200\u2005mg and 400\u2005mg\/kg, bw for aqueous\u2010based propolis extract.<\/jats:p>","DOI":"10.1002\/cbdv.202300305","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T19:23:05Z","timestamp":1681500185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Protective Effect of Aqueous and Ethanolic Extracts of Propolis against Gastric Ulceration in Rats"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-1494","authenticated-orcid":false,"given":"Huseyin","family":"Sahin","sequence":"first","affiliation":[{"name":"Espiye Vocational School Giresun University  Espiye Giresun T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4995-2657","authenticated-orcid":false,"given":"Kaan","family":"Kaltalioglu","sequence":"additional","affiliation":[{"name":"Espiye Vocational School Giresun University  Espiye Giresun T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-6542","authenticated-orcid":false,"given":"Zuleyha","family":"Erisgin","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine Giresun University  Giresun T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-2845","authenticated-orcid":false,"given":"Sule","family":"Coskun\u2010Cevher","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Sciences Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-6139","authenticated-orcid":false,"given":"Sevgi","family":"Kolayli","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences Karadeniz Technical University  Trabzon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.06.041"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00087"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102355"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JFOODENG.2009.08.040"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12161-022-02244-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2022.100239"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2018.11.007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1363755"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JEP.2006.10.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","unstructured":"C. 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