{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:24:08Z","timestamp":1782739448002,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the last few years, the interest in sulfonamides has expanded owing to their broad spectrum of biological activities. Their flexible structure turns them into amazing candidates to replace old drugs or develop modern multi\u2010target agents. In this study, a series of new sulfonamides (<jats:bold>sul1\u20105<\/jats:bold>) was evaluated,<jats:italic>in\u2005vitro<\/jats:italic>, for the antibacterial, cytotoxic and genotoxic effects. The antibacterial activity was investigated against 12 clinical and 4 reference strains. Cytotoxic activity was carried out by the brine shrimp bioassay and the genotoxicity was assessed in the Ames test. An interesting antibacterial activity was showed especially against Gram negative strains. The inhibition zones varied between 15 and 30\u2005mm, and the Minimum Inhibitory Concentrations (MIC's) values between 0.5 and 256\u2005\u03bcg\/ml. No antibacterial activity was shown with<jats:italic>S.\u2005aureus<\/jats:italic>isolates. Only<jats:bold>Sul1<\/jats:bold>and<jats:bold>Sul4<\/jats:bold>were active against<jats:italic>P.\u2005aeruginosa<\/jats:italic>. Compounds<jats:bold>Sul1<\/jats:bold>and<jats:bold>Sul2<\/jats:bold>showed a significant cytotoxicity with LC<jats:sub>50<\/jats:sub>equal to 18.29 and 18\u2005\u03bcg\/ml respectively, and a genotoxic effect against TA100 and TA1535<jats:italic>Salmonella<\/jats:italic>strains. Only compounds<jats:bold>Sul3<\/jats:bold>,<jats:bold>Sul4<\/jats:bold>and<jats:bold>Sul5<\/jats:bold>with an interesting antibacterial activity, no cytotoxicity and no genotoxic effects, could be exploited against resistant pathogens as new drugs.<\/jats:p>","DOI":"10.1002\/cbdv.202300505","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T02:05:33Z","timestamp":1691028333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antibacterial, Cytotoxic and Genotoxic Assessment of New Sulfonamide Derivatives"],"prefix":"10.1002","volume":"20","author":[{"given":"Becheker","family":"Im\u00e8ne","sequence":"first","affiliation":[{"name":"Research Laboratory of Interactions Biodiversity Ecosystems and Biotechnology Faculty of Sciences University August 20, 1955 21000 Skikda Algeria"},{"name":"Laboratory of Applied Biochemistry and Microbiology Faculty of Sciences Badji Mokhtar University 23000 Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melakhessou Mohamed","family":"Akram","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology of Bioactive Molecules and Cellular Physiopathology University of Batna-2 05000 Batna Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marref Salah","family":"Eddine","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology of Bioactive Molecules and Cellular Physiopathology University of Batna-2 05000 Batna Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grib","family":"Ismahene","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Organic Chemistry Faculty of Sciences Badji Mokhtar University 23000 Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-0156","authenticated-orcid":false,"given":"Mounia","family":"Amarouayache","sequence":"additional","affiliation":[{"name":"Marine Bioresources Laboratory Faculty of Sciences Badji Mokhtar University 23000 Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-8771","authenticated-orcid":false,"given":"Malika","family":"Berredjem","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Organic Chemistry Faculty of Sciences Badji Mokhtar University 23000 Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9690-778X","authenticated-orcid":false,"given":"Hajira","family":"Berredjem","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry and Microbiology Faculty of Sciences Badji Mokhtar University 23000 Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08093-x"},{"key":"e_1_2_10_2_1","volume-title":"Fluoroquinolone antibacterial drugs: Veterinary Pharmacology and Therapeutics","author":"Papich M. 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