{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T21:29:15Z","timestamp":1773437355817,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In our previous work, two dopamine derivatives with benzothiazole fragment were isolated and identified from <jats:italic>Polyrhachis dives<\/jats:italic> (<jats:italic>P. dives<\/jats:italic>). Based on their characteristic structure, we used them as lead compound to carry out structural optimization and subsequent fungicidal evaluation. Here 20 dopamine derivatives with benzothiazole fragment were designed and synthesized by a facile method, and their structures were characterized by <jats:sup>1<\/jats:sup>H\u2010NMR, <jats:sup>13<\/jats:sup>CNMR and HMRS. In bioassays, most of the title compounds possess potential fungicidal activities against <jats:italic>Altenaia alternala<\/jats:italic> (<jats:italic>A. alternala<\/jats:italic>) and <jats:italic>Botrytis cinerea<\/jats:italic> (<jats:italic>B. cinerea<\/jats:italic>). Especially, (<jats:italic>E<\/jats:italic>)\u2010<jats:italic>N<\/jats:italic>\u2010(2\u2010(benzo[<jats:italic>d<\/jats:italic>]thiazol\u20106\u2010yl)ethyl)\u20103\u2010(<jats:italic>p\u2010<\/jats:italic>tolyl)acrylamide and (<jats:italic>E<\/jats:italic>)\u2010<jats:italic>N<\/jats:italic>\u2010(2\u2010(benzo[<jats:italic>d<\/jats:italic>]thiazol\u20106\u2010yl)ethyl)\u20103\u2010(4\u2010(trifluoromethyl)phenyl)acrylamide displayed 29.3\u2005mg\/L and 10.7\u2005mg\/L EC<jats:sub>50<\/jats:sub> value against <jats:italic>A. alternala<\/jats:italic>, respectively, which possessed equivalent fungicidal activities level to hymexazol.<\/jats:p>","DOI":"10.1002\/cbdv.202300533","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T21:52:37Z","timestamp":1686088357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Structural Optimization, Fungicidal Activities Evaluation, DFT Study and Structure\u2010Activity Relationship of Dopamine Derivatives with Benzothiazole Fragment from <i>Polyrhachis dives<\/i>"],"prefix":"10.1002","volume":"20","author":[{"given":"Yaxuan","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenzhen University Medical School Shenzhen University  Shenzhen 518055 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-6192","authenticated-orcid":false,"given":"Danling","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenzhen University Medical School Shenzhen University  Shenzhen 518055 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-9598","authenticated-orcid":false,"given":"Yong\u2010Xian","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenzhen University Medical School Shenzhen University  Shenzhen 518055 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1080\/03601230701316465"},{"key":"e_1_2_9_2_1","first-page":"89","volume":"13","author":"Lorite P.","year":"2010","journal-title":"Myrmecol. 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