{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:33:14Z","timestamp":1790710394003,"version":"4.1.0"},"reference-count":93,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Artemisia annua<\/jats:italic>\n                    L. (Asteraceae Family) is an important plant in Asia that has been used for treating different diseases, including fever due to malaria, wounds, tubercolisis, scabues, pain, convulsions, diabetes, and inflammation. In this study we aimed to evaluate the effects of different polarity extracts (hexane, dichloromethane, ethyl acetate, ethanol, ethanol\/water (70\u2009%) and water) from\n                    <jats:italic>A. annua<\/jats:italic>\n                    against the burden of inflammation and oxidative stress occurring in colon tissue exposed to LPS. In parallel, chemical composition, antiradical, and enzyme inhibition effects against \u03b1\u2010amylase, \u03b1\u2010glucosidase, tyrosinase, and cholinesterases were evaluated. The water extract contained the highest content of the total phenolic with 34.59\u2005mg gallic acid equivalent (GAE)\/g extract, while the hexane had the highest content of the total flavonoid (20.06\u2005mg rutin equivalent (RE)\/g extract). In antioxidant assays, the polar extracts (ethanol, ethanol\/water and water) exhibited stronger radical scavenging and reducing power abilities when compared to non\u2010polar extracts. The hexane extract showed the best AChE, tyrosinase and glucosidase inhibitory effects. All extracts revealed effective anti\u2010inflammatory agents, as demonstrated by the blunting effects on COX\u20102 and TNF\u03b1 gene expression. These effects seemed to be not related to the only phenolic content. However, it is worthy of interest to highlight how the higher potency against LPS\u2010induced gene expression was shown by the water extract ; thus suggesting a potential phytotherapy application in the management of clinical symptoms related to inflammatory colon diseases, although future in\u2005vivo studies are needed to confirm such in\u2005vitro and ex vivo observations.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202300547","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T11:06:48Z","timestamp":1686568008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Chemical Characterization of Different Extracts from\n                    <i>Artemisia annua<\/i>\n                    and Their Antioxidant, Enzyme Inhibitory and Anti\u2010Inflammatory Properties"],"prefix":"10.1002","volume":"20","author":[{"given":"Alessandra","family":"Acquaviva","sequence":"first","affiliation":[{"name":"Department of Pharmacy G. d'Annunzio University of Chieti-Pescara  66100 Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nilofar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy G. d'Annunzio University of Chieti-Pescara  66100 Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhakim","family":"Bouyahya","sequence":"additional","affiliation":[{"name":"Laboratory of Human Pathologies Biology Faculty of Sciences Department of Biology Mohammed V University in Rabat  1014 Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-7823","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Physiology and Biochemistry Laboratory Department of Biology 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