{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:44:28Z","timestamp":1789065868760,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chemical investigation of the rarely studied soft coral <jats:italic>Sinularia tumulosa<\/jats:italic> resulted in the discovery of five oxygenated cembrane diterpenes <jats:bold>1<\/jats:bold>\u2013<jats:bold>5<\/jats:bold>, including two new compounds situmulins A (<jats:bold>1<\/jats:bold>) and B (<jats:bold>2<\/jats:bold>). The structures of <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> were established through the extensive analyses of 1D and 2D NMR spectral data together with the comparisons with the known compounds. Furthermore, the absolute configuration of <jats:bold>1<\/jats:bold> was determined by the time\u2010dependent density functional theory (TDDFT) ECD approach, while the relative configuration of <jats:bold>2<\/jats:bold> was assigned via the quantum mechanical\u2010NMR (QM\u2010NMR) calculations. It might be worth to point out it is the first time to disclose the presence of cembrane diterpenes in the title species. In the bioassays, compound <jats:bold>2<\/jats:bold> not only showed strong antibacterial activities against fish pathogenic bacteria <jats:italic>Streptococcus parauberis<\/jats:italic> FP KSP28 and <jats:italic>Phoyobacterium damselae<\/jats:italic> FP2244 with both minimum inhibitory concentration for 90\u2009% (MIC<jats:sub>90<\/jats:sub>) values of 25\u2005\u03bcM, but also demonstrated substantial inhibitory efficacy against vancomycin\u2010resistant <jats:italic>Enterococcus faecium<\/jats:italic> bacteria G1, G4, G7, G8 and G13 from several individuals, with MIC<jats:sub>90<\/jats:sub> values of 25, 50, 100, 50 and 25\u2005\u03bcM, respectively.<\/jats:p>","DOI":"10.1002\/cbdv.202300589","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T05:07:50Z","timestamp":1685509670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oxygenated Cembrane Diterpenes from the South China Sea Soft Coral <i>Sinularia tumulosa<\/i>**"],"prefix":"10.1002","volume":"20","author":[{"given":"Sheng\u2010Hui","family":"Zhu","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"},{"name":"State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan\u2010Dan","family":"Yu","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai 264117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Zhi","family":"Su","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai 264117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Zhanjiang for Research and Development Marine Microbial Resources in the Beibu Gulf Rim Marine Biomedical Research Institute Guangdong Medical University  Zhanjiang 524023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Gong","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7453-5572","authenticated-orcid":false,"given":"Lin\u2010Fu","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Central South University of Forestry and Technology  498 South Shaoshan Road Changsha 410004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0058-060X","authenticated-orcid":false,"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 310014 China"},{"name":"State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park Shanghai 201203 China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai 264117 China"},{"name":"Open Studio for Druggability Research of Marine Natural Products Pilot National Laboratory for Marine Science and Technology (Qingdao)  1 Wenhai Road, Aoshanwei, Jimo Qingdao 266237 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NP00083K"},{"key":"e_1_2_9_2_1","first-page":"643","volume":"40","author":"Liang L.-F.","year":"2013","journal-title":"J. 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