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Based on these two groups, the synthesis of new compounds is important. In the present study, the novel 1,3\u2010diaryltriazene\u2010substituted sulfaguanidine derivatives (\n                    <jats:bold>SG1\u201013<\/jats:bold>\n                    ) were synthesized and fully characterized by spectroscopic and analytic methods. Inhibitory effect of these compounds on the\n                    <jats:italic>h<\/jats:italic>\n                    CA I and hCA II was screened as in\u2005vitro. All the series of synthesized compounds have been identified as potential\n                    <jats:italic>h<\/jats:italic>\n                    CA isoenzymes inhibitory with\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>I<\/jats:sub>\n                    values in the range of 6.44\u00b10.74\u201086.85\u00b17.01\u2005nM for\n                    <jats:italic>h<\/jats:italic>\n                    CA I and with\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>I<\/jats:sub>\n                    values in the range of 8.16\u00b10.40\u201077.29\u00b19.56\u2005nM for\n                    <jats:italic>h<\/jats:italic>\n                    CA II. Moreover, the new series of compounds showed a more effective inhibition effect than the acetazolamide used as a reference. The possible binding positions of the compounds with a binding affinity to the\n                    <jats:italic>h<\/jats:italic>\n                    CA I and\n                    <jats:italic>h<\/jats:italic>\n                    CA II was demonstrated by in silico studies. In conclusion, compounds with varying degrees of affinity for\n                    <jats:italic>h<\/jats:italic>\n                    CA isoenzymes have been designed and as selective\n                    <jats:italic>h<\/jats:italic>\n                    CA inhibitors. These compounds may be potential alternative agents that can be used to treat or prevent diseases associated with glaucoma and\n                    <jats:italic>h<\/jats:italic>\n                    CA inhibition.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202300611","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T11:15:17Z","timestamp":1689851717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis and Characterization of Novel 1,3\u2010Diaryltriazene\u2010Substituted Sulfaguanidine Derivatives as Selective Carbonic Anhydrase Inhibitors: Biological Evaluation,\n                    <i>in Silico<\/i>\n                    ADME\/T and Molecular Docking 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