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Different factors including geographical, genetic, hormonal, oral contraceptives and modern lifestyle could be responsible for the development of breast cancer and different pathways can be targeted for breast cancer treatment. The various conventional approaches used for the treatment of breast cancer including radiotherapy, chemotherapy, hormone and immunotherapy. But due to the side effects associated with these conventional treatments such as non\u2010selectivity, multidrug resistance and bioavailability, there is a need for the development of better therapeutic agents for breast cancer treatment. Several natural products have been explored for breast cancer treatment. However, many of these natural products suffered from the limitations of poor water solubility and possess toxic side effects. To overcome these limitations, several structural analogs of natural products have been synthesized and possess potent anti\u2010breast cancer effects with less side effects over their precursor molecules. In the present manuscript, we describe the pathogenesis of breast cancer, some potent natural products used in the treatment of breast cancer and their selected structural analogs possessing potent anti\u2010breast cancer effects. Database such as Science direct, Pubmed and Google scholar were searched using keywords \u2018risk factors\u2019, \u2018screening methods\u2019,'receptors\u2019, and \u2018natural products and derivatives\u2019, Registered clinical trials on selected natural products were also analyzed. Present study concludes that eight selected natural products and their derivatives possess wide potential to exhibit anti\u2010breast cancer effects and could be explored further to develop better chemotherapeutic agents against breast cancer.<\/jats:p>","DOI":"10.1002\/cbdv.202300688","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T12:13:00Z","timestamp":1689077580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Concise Review on Natural Products and Their Derivatives for Breast Cancer Treatment"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2565-2446","authenticated-orcid":false,"given":"Nidhi","family":"Gupta","sequence":"first","affiliation":[{"name":"M. M. 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