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Studies have proved that phyto\u2010compounds based on biosynthetic metallic nanoparticles display superior action against hepatic tumors. This study targeted the synthesis of genistein\u2010fortified zinc ferrite nanoparticles (GENP) trailed by anticancer activity assessment against diethylnitrosamine and <jats:italic>N<\/jats:italic>\u2010acetyl\u20102\u2010aminofluorene induced hepatic cancer. The process of nucleation was confirmed by UV\/VIS spectrophotometry, X\u2010ray beam diffraction, field\u2010emission scanning electron microscopy, and FT\u2010IR. An <jats:italic>in\u2005vitro<\/jats:italic> antioxidant assay illustrated that the leaves of <jats:italic>Pterocarpus mildbraedii<\/jats:italic> have strong tendency as a reductant and, in the nanoformulation synthesis, as a natural capping agent. A MTT assay confirmed that GENP have a strong selective cytotoxic potential against HepG2 cancer cells. <jats:italic>In silico<\/jats:italic> studies of genistein exemplified the binding tendency towards human matrix metalloproteinase comparative to the standard drug marimastat. 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