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Their efficiency was determined in terms of the qualitative and quantitative composition in phenolic compounds by HPLC\u2010LC\/MS of the different extracts isolated from C. Benedictus roots. Cnicus benedictus roots extract have been characterized by high content of phenolic compounds, where the trans chalcone, 2,3\u2010dihydro flavone, 3\u2010hydroxy flavone and cinnamic acid constitute the major components, in addition to fourteen minor acidic compounds and flavonoids as rutin. The hydro\u2010methanolic extract was the richest in phenolic compounds yield from <jats:italic>C benedictus<\/jats:italic>. On the other hand, hydro methanolic (30\u2009:\u200970, v\/v) and hydro ethanolic (30\u2009:\u200970, v\/v) extracts exhibited a high anti\u2010inflammatory activity by in\u2005vitro 5\u2010lipoxygenase inhibitory activity (IC<jats:sub>50<\/jats:sub>: 6.05\u00b194.16\u2005\u03bcg\/mL) as well as by in silico docking according two methods. Likewise, anti\u2010Alzheimer activity of extracts was confirmed by this last technique taking into account the major compounds identified. Antibacterial tests revealed interesting results compared to amoxicillin for the different regions studied with a high content in trans chalcone and 3\u2010hydroxy Flavone.<\/jats:p>","DOI":"10.1002\/cbdv.202300724","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T07:18:27Z","timestamp":1700810307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["HPLC\/ESI\u2010MS Characterization of Phenolic Compounds from <i>Cnicus benedictus<\/i> L. Roots: A Study of Antioxidant, Antibacterial, Anti\u2010Inflammatory, and Anti\u2010Alzheimer's Activity"],"prefix":"10.1002","volume":"21","author":[{"given":"Khalid","family":"Rezig","sequence":"first","affiliation":[{"name":"Ecole Normale Sup\u00e9rieure El Bachir El-Ibrahimi (E.N.S) Ecology and Animal Laboratory Department of Biology, BP 92  Kouba-Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Benkaci\u2010Ali","sequence":"additional","affiliation":[{"name":"University of Sciences and Technology HouariBoumediene (U.S.T.H.B) Laboratory of Functional Organic Analysis Department of Organic Chemistry Faculty of Chemistry, El Alia, BP 32, Bab Ezzouar  16111 Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure","family":"Fauconnier","sequence":"additional","affiliation":[{"name":"University of Li\u00e8ge <sup>c<\/sup> Laboratory of Chemistry of Natural Molecules Gembloux Agro-Bio Tech  Passage des D\u00e9port\u00e9s 2 B-5030 Gembloux Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Laurent","sequence":"additional","affiliation":[{"name":"University of Mons Unit of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory  20, Place du Parc B-7000 Mons Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruna Isiyaku","family":"Umar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Federal University of Technology  Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omoboyowa Damilola","family":"Alex","sequence":"additional","affiliation":[{"name":"Biochemical Pharmacology and Computational Biology Unit Department of Biochemistry Adekunle Ajasin University  Akungba-Akoko Ondo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Tata","sequence":"additional","affiliation":[{"name":"Ecole Normale Sup\u00e9rieure El Bachir El-Ibrahimi (E.N.S) Ecology and Animal Laboratory Department of Biology, BP 92  Kouba-Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2015.07.073"},{"key":"e_1_2_9_2_1","first-page":"308","volume":"5","author":"Can Z.","year":"2017","journal-title":"Turk. 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