{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T10:17:25Z","timestamp":1787480245862,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008347","name":"Bezmialem Vak\u0131f \u00dcniversitesi","doi-asserted-by":"publisher","award":["20220420"],"award-info":[{"award-number":["20220420"]}],"id":[{"id":"10.13039\/501100008347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, twenty new anthranilic acid hydrazones <jats:bold>6<\/jats:bold>\u2013<jats:bold>9<\/jats:bold> (<jats:bold>a<\/jats:bold>\u2013<jats:bold>e<\/jats:bold>) were synthesized and their structures were characterized by Fourier\u2010transform Infrared (FT\u2010IR), Nuclear Magnetic Resonance (<jats:sup>1<\/jats:sup>H\u2010NMR \u2013 <jats:sup>13<\/jats:sup>C\u2010NMR), and High\u2010resolution Mass Spectroscopy (HR\u2010MS). The inhibitory effects of the compounds against COX\u2010II were evaluated. IC<jats:sub>50<\/jats:sub> values of the compounds were found in the range of &gt;200\u20130.32\u2005\u03bcM and compounds <jats:bold>6e<\/jats:bold>, <jats:bold>8d<\/jats:bold>, <jats:bold>8e<\/jats:bold>, <jats:bold>9b<\/jats:bold>, <jats:bold>9c<\/jats:bold>, and <jats:bold>9e<\/jats:bold> were determined to be the most effective inhibitors. Cytotoxic effects of the most potent compounds were investigated against human hepatoblastoma (Hep\u2010G2) and human healthy embryonic kidney (Hek\u2010293) cell lines. Doxorubicin (IC<jats:sub>50<\/jats:sub>: 8.68\u00b10.16\u2005\u03bcM for Hep\u2010G2, 55.29\u00b10.56\u2005\u03bcM for Hek\u2010293) was used as standard. <jats:bold>8e<\/jats:bold> is the most active compound, with low IC<jats:sub>50<\/jats:sub> against Hep\u2010G2 (4.80\u00b10.04\u2005\u03bcM), high against Hek\u2010293 (159.30\u00b13.12), and high selectivity (33.15). Finally, molecular docking and dynamics studies were performed to understand ligand\u2010protein interactions between the most potent compounds and COX\u2005II, Epidermal Growth Factor Receptor (EGFR), and Transforming Growth Factor beta\u2005II (TGF\u2010\u03b2II). The docking scores were calculated in the range of \u221210.609\u2013\u22126.705\u2005kcal\/mol for COX\u2010II, \u22128.652\u2013\u22127.743\u2005kcal\/mol for EGFR, and \u221210.708\u2013\u22128.596\u2005kcal\/mol for TGF\u2010\u03b2II.<\/jats:p>","DOI":"10.1002\/cbdv.202300773","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T20:09:40Z","timestamp":1688069380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["New Anthranilic Acid Hydrazones as Fenamate Isosteres: Synthesis, Characterization, Molecular Docking, Dynamics &amp; <i>in Silico<\/i> ADME, <i>in Vitro<\/i> Anti\u2010Inflammatory and Anticancer Activity Studies"],"prefix":"10.1002","volume":"20","author":[{"given":"Halil","family":"\u015eenol","sequence":"first","affiliation":[{"name":"Bezmialem Vakif University Faculty of Pharmacy Department of Pharmaceutical Chemistry  Fatih 34093 Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"\u00c7a\u011fman","sequence":"additional","affiliation":[{"name":"Bezmialem Vakif University Faculty of Pharmacy Department of Biochemistry  Fatih 34093 Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"Gen\u00e7o\u011flu Katmerlikaya","sequence":"additional","affiliation":[{"name":"Bezmialem Vakif University Institute of Health Sciences Department of Biotechnology  34093 \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5532-8802","authenticated-orcid":false,"given":"Feyzi","family":"Sinan Tokal\u0131","sequence":"additional","affiliation":[{"name":"Kafkas University Kars Vocational School Department of Material and Material Processing Technologies  36100 Kars T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2048731"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar116"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.10.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15121471"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.11.033"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2014.866943"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-012-9375-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.04.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.137"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12612"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70490-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00513-6"},{"key":"e_1_2_10_14_1","first-page":"319","volume":"18","author":"Grothey A.","year":"2020","journal-title":"Clin. 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