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A virtual set of quinoline derivatives was verified with a previously published classification model of anti\u2010E. coli activity and screened using the regression model of anti\u2010S. aureus activity. Selected and synthesized 2(4)\u2010hydrazone derivatives of quinoline exhibited antibacterial activity against the standard and antibiotic\u2010resistant<jats:italic>S. aureus<\/jats:italic>and<jats:italic>E. coli<\/jats:italic>strains in the range from 15 to 30\u2005mm by the diameter of growth inhibition zones. Molecular docking showed the complex formation of the studied compounds into the catalytic domain of dihydrofolate reductase with an estimated binding affinity from \u22128.4 to \u22129.4\u2005kcal\/mol.<\/jats:p>","DOI":"10.1002\/cbdv.202300839","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T16:14:02Z","timestamp":1691511242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quinoline Hydrazone Derivatives as New Antibacterials against Multidrug Resistant Strains"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-9833","authenticated-orcid":false,"given":"Diana","family":"Hodyna","sequence":"first","affiliation":[{"name":"V.P. 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