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The World Health Organization also mentions that medicinal plants remain at the center for meeting primary healthcare needs as the population relies on them. The plant\u2010derived natural products have remained an attractive choice for drug development owing to their specific biological functions relevant to human health and also the high degree of potency and specificity they offer. In this context, one such esteemed phytoconstituent with inexplicable biological potential is psoralen, a furanocoumarin. Psoralen was the first constituent isolated from the plant<jats:italic>Psoralea corylifolia<\/jats:italic>, commonly known as Bauchi. Despite being a life\u2010saver for psoriasis, vitiligo, and leukoderma, it also showed immense anticancer, anti\u2010inflammatory, and anti\u2010osteoporotic potential. This review brings attention to the possible application of psoralen as an attractive target for rational drug design and medicinal chemistry. It discusses the various methods for the total synthesis of psoralen, its extraction, the pharmacological spectrum of psoralen, and the derivatization done on psoralen.<\/jats:p>","DOI":"10.1002\/cbdv.202300867","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T05:46:14Z","timestamp":1695793574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Phytochemical and Pharmacological Aspects of Psoralen \u2013 A Bioactive Furanocoumarin from<i>Psoralea corylifolia<\/i>Linn."],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4193-6748","authenticated-orcid":false,"given":"Nancy","family":"Tripathi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering &amp; Technology Indian Institute of Technology BHU Varanasi 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7857-9441","authenticated-orcid":false,"given":"Nivedita","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering &amp; Technology Indian Institute of Technology BHU Varanasi 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering &amp; Technology Indian Institute of Technology BHU Varanasi 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-8755","authenticated-orcid":false,"given":"Shreyans K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering &amp; Technology Indian Institute of Technology BHU Varanasi 221005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"e_1_2_18_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.08.001"},{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13237-022-00405-3"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6628"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00139.x"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-44930-8_9"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01101-X"},{"key":"e_1_2_18_7_1","doi-asserted-by":"crossref","unstructured":"S.\u2005J. 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