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Dichloromethane sub\u2010extract displayed the highest activity and was chosen for further investigation. Despite the widespread use of <jats:italic>E. angustifolium<\/jats:italic>, genotoxicity studies were conducted to assess its safety. Dichloromethane significantly inhibited \u03b1\u2010glucosidase (IC<jats:sub>50<\/jats:sub>=17.340\u2005\u03bcg\/mL), making it approximately 293\u2005times more effective than acarbose. Six known compounds, including gallic acid (1), a mixture of quercetin\u20103\u2010O\u2010\u03b1\u2010galactoside (2a) and quercetin\u20103\u2010O\u2010\u03b1\u2010glucoside (2b), quercetin\u20103\u2010O\u2010\u03b1\u2010glucuronic acid (3), quercetin\u20103\u2010O\u2010\u03b1\u2010rhamnoside (4), and kaempferol\u20103\u2010O\u2010\u03b1\u2010rhamnoside (5) were identified. Quercetin\u20103\u2010O\u2010\u03b1\u2010rhamnoside exhibited the highest inhibition of \u03b1\u2010glucosidase (IC<jats:sub>50<\/jats:sub>=1735\u00b185\u2005\u03bcM), making it 3.70\u2005times more effective than acarbose. Dichloromethane also showed significant antigenotoxic activity against mutagenesis induced by NaN3, 9\u2010AA, 4\u2010NPD, and MNNG. Gallic acid was found in the highest abundance (13253.6931\u2005ng\/mL) in the methanolic extract. Furthermore, L\u2010Aspartic acid was the most concentrated amino acid (363.5620\u2005nmol\/mL) in the methanolic extract.<\/jats:p>","DOI":"10.1002\/cbdv.202300922","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T06:15:57Z","timestamp":1700806557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Phytochemical Analysis and Evaluation of Genotoxic, Antigenotoxic Effects in Bacterial Models, and Hypoglycemic Activity of <i>Epilobium angustifolium<\/i> L. with Bioguided Isolation of Active Compounds"],"prefix":"10.1002","volume":"20","author":[{"given":"Hafize","family":"Yuca","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ataturk University  Erzurum Turkey"},{"name":"Medicinal and Aromatic Plant and Drug Research Center Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Karaday\u0131","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Science Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-721X","authenticated-orcid":false,"given":"Song\u00fcl","family":"Karakaya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"Civa\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ataturk University  Erzurum Turkey"},{"name":"Department of Pharmacy and Pharmaceutical Services Igdir University  Igdir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enes","family":"Tekman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuhal","family":"Guvenalp","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ataturk University  Erzurum Turkey"},{"name":"Medicinal and Aromatic Plant and Drug Research Center Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2222-1808(12)60054-1"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112264"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497580"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2018.6.181"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2478\/hepo-2019-0018"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2020.104638"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2021.104645"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(01)01046-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(01)01067-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901827"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-022-01752-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3059"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21414"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711416954"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233712456060"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713484649"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233717730492"},{"key":"e_1_2_11_18_1","first-page":"13276","volume":"23","author":"Tugcu F. 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