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Salicylic acid can not only regulate some important growth metabolism of plants, but also induce plant disease resistance. The bioassay results showed that the salicylamides exhibited excellent antibacterial activity. Especially, oxyclozanide showed the best antibacterial effect against <jats:italic>Xanthomonas oryzae<\/jats:italic>, <jats:italic>Xanthomonas axonopodis<\/jats:italic> pv. <jats:italic>citri<\/jats:italic> and <jats:italic>Pectobacterium atroseptica<\/jats:italic> with MICs of 0.78, 3.12 and 12.5\u2005\u03bcg.mL\u20101, respectively. In vivo experiments with rice bacterial leaf blight had further demonstrated that oxyclozanide exhibited stronger antibacterial activity than the commercial bactericide, thiodiazole copper. Oxyclozanide could induce plant defense responses through the determination of salicylic acid content and the activities of defense\u2010related enzymes including CAT, POD, and SOD in rice. The preliminarily antibacterial mechanism study indicated that oxyclozanide exhibited the antibacterial activity by disrupting cell integrity and reducing bacterial pathogenicity. Additionally, oxyclozanide could induce plant defense responses through the determination of salicylic acid content.<\/jats:p>","DOI":"10.1002\/cbdv.202300998","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T13:20:21Z","timestamp":1695734421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Repurposing Salicylamides to Combat Phytopathogenic Bacteria and Induce Plant Defense Responses"],"prefix":"10.1002","volume":"20","author":[{"given":"Yue","family":"Ma","sequence":"first","affiliation":[{"name":"School of Pharmacy Lanzhou University  Lanzhou 730000 P. R. 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