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However, its efficacy is reduced by the overexpression of ABC transporters, which are proteins that expel the drugs used in chemotherapy and involved in the multidrug resistance (MDR). Glycolipids have been identified as potential inhibitors of ABC transporters. Algae of the genus <jats:italic>Sargassum<\/jats:italic> contain high levels of glycolipids, making them a promising therapeutic alternative against the MDR phenotype. <jats:italic>Sargassum filipendula<\/jats:italic> glycolipids were obtained by exhaustive maceration with chloroform\/methanol, purified by column and thin layer chromatography, and then characterized by FTIR, NMR, and LC\u2010MS. Cell viability by PI labeling and inhibition of ABC transporters were analyzed by flow cytometry. Assessment of resistance reversal was determined by MTT assay. Ten sulfoquinovosylglycerol\u2010type compounds were found, and six of them are reported for the first time. In particular, moiety 4 (GL\u20104) showed strong and moderate inhibitory activity against ABCC1 and ABCB1 transporters respectively. Treatment of GL\u20104 in combination with the antineoplastic drug vincristine sensitized Lucena\u20101\u2005cell model to drug and reversed the MDR phenotype. This is the first report of glycolipids isolated from <jats:italic>S. filipendula<\/jats:italic> capable of inhibiting ABC transporters and thus overcoming acquired drug resistance.<\/jats:p>","DOI":"10.1002\/cbdv.202301058","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T15:53:52Z","timestamp":1695657232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glycolipids from <i>Sargassum filipendula<\/i>, a Natural Alternative for Overcoming ABC Transporter\u2010Mediated MDR in Cancer"],"prefix":"10.1002","volume":"20","author":[{"given":"Kelly","family":"Mu\u00f1oz\u2010Losada","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Compuestos Funcionales Facultad de Ciencias Exactas y Naturales Universidad de Antioquia UdeA  Calle 70 No. 52\u201321 Medell\u00edn 050010 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli Monteiro","family":"Da Costa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Glicobiologia Instituto de Biof\u00edsica Carlos Chagas Filho Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro 21941-902 Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Mu\u00f1oz\u2010Castiblanco","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Compuestos Funcionales Facultad de Ciencias Exactas y Naturales Universidad de Antioquia UdeA  Calle 70 No. 52\u201321 Medell\u00edn 050010 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Camilo","family":"Mej\u00eda\u2010Giraldo","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Compuestos Funcionales Facultad de Ciencias Exactas y Naturales Universidad de Antioquia UdeA  Calle 70 No. 52\u201321 Medell\u00edn 050010 Colombia"},{"name":"Facultad de Ciencias Farmac\u00e9uticas y Alimentarias Universidad de Antioquia UdeA  Calle 70 No. 52\u201321 Medell\u00edn 050010 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Osvaldo","family":"Previato","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Glicobiologia Instituto de Biof\u00edsica Carlos Chagas Filho Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro 21941-902 Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Mendon\u00e7a\u2010Previato","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Glicobiologia Instituto de Biof\u00edsica Carlos Chagas Filho Universidade Federal do Rio de Janeiro (UFRJ)  Rio de Janeiro 21941-902 Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Puertas\u2010Mej\u00eda","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Compuestos Funcionales Facultad de Ciencias Exactas y Naturales Universidad de Antioquia UdeA  Calle 70 No. 52\u201321 Medell\u00edn 050010 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_8_2_1","unstructured":"\u201cWorld Health Organization \u201dcan be found underhttps:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer\/ 2022(accessed 13 June 2023)."},{"key":"e_1_2_8_3_1","unstructured":"National Cancer Institute \u201cCancer Basics \u201d can be found underhttps:\/\/www.cancer.gov\/about-cancer\/treatment\/types 2022(accessed 13 June 2023)."},{"key":"e_1_2_8_4_1","first-page":"215","volume":"39","author":"Dickens E.","year":"2021","journal-title":"Surg."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12581"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21652"},{"key":"e_1_2_8_7_1","first-page":"130","author":"Gabriel Janice Ann","year":"2007","journal-title":"The Biology of Cancer, England"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60984-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.02.017"},{"key":"e_1_2_8_10_1","first-page":"15","volume":"31","author":"Bar-Zeev M.","year":"2017","journal-title":"Drug Resist. 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