{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T06:27:38Z","timestamp":1782023258345,"version":"3.54.5"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> colonizes the gastric epithelium of 50\u2009% of world population and it is the main etiological agent of human chronic gastritis, peptic ulcer, and gastric cancer. In this study, we synthesized and characterized a series of 14 chalcones and evaluated their anti\u2010<jats:italic>H. pylori<\/jats:italic>, NO inhibition (<jats:italic>in\u2005vitro<\/jats:italic> and <jats:italic>in silico<\/jats:italic>), and AGS cells cytotoxic effects. Compounds <jats:bold>3b<\/jats:bold> and <jats:bold>3h<\/jats:bold> showed MIC of 8\u2005\u03bcg\/mL. We observed structure\u2010activity relationships, mainly related to the influence of methoxy substituent at C\u20102 (<jats:bold>3b<\/jats:bold>) and the nitro group at C\u20104 (<jats:bold>3h<\/jats:bold>) in chalcone scaffold. The fourteen chalcones inhibited the NO production in LPS\u2010stimulated macrophages and showed potential for interaction on the active site of the iNOS enzyme. Finally, <jats:bold>3b<\/jats:bold> and <jats:bold>3h<\/jats:bold> showed the highest selectivity to the AGS cell lines. Thus, ours results suggest <jats:bold>3b<\/jats:bold> and <jats:bold>3h<\/jats:bold> as potential candidates for design of new and effective agents against <jats:italic>H. pylori<\/jats:italic> and related diseases.<\/jats:p>","DOI":"10.1002\/cbdv.202301066","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T14:24:25Z","timestamp":1693405465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis, Docking Studies and Evaluation of Chalcones as Anti\u2010<i>Helicobacter pylori<\/i> and antitumoral Agents"],"prefix":"10.1002","volume":"20","author":[{"given":"Jessica Rodrigues","family":"Pereira de Oliveira Borlot","sequence":"first","affiliation":[{"name":"Graduate Program of Pharmaceutical Sciences Health Sciences Center Federal University of Esp\u00edrito Santo  Avenida Marechal Campos 1468, Bonfim 29047-105 Vit\u00f3ria ES Brazil"},{"name":"Graduate Program of Chemistry Exact Sciences Center Federal University of Esp\u00edrito Santo  Avenida Fernando Ferrari 514, Goiabeiras 29075-910 Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Schlittler dos Santos","sequence":"additional","affiliation":[{"name":"Department of Chemistry Exact Sciences Center Federal University of Esp\u00edrito Santo  Avenida Fernando Ferrari 514, Goiabeiras 29075-910 Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Jos\u00e9","family":"Schwarzt Sampaio","sequence":"additional","affiliation":[{"name":"Graduate Program of Pharmaceutical Sciences Health Sciences Center Federal University of Esp\u00edrito Santo  Avenida Marechal Campos 1468, Bonfim 29047-105 Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Santos Borges","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Health Sciences Center Federal University of Esp\u00edrito Santo  Avenida Marechal Campos 1468, Bonfim 29047-105 Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Pereira","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Graduate Program of Pharmaceutical Sciences Health Sciences Center Federal University of Esp\u00edrito Santo  Avenida Marechal Campos 1468, Bonfim 29047-105 Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"de C\u00e1ssia Ribeiro Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Graduate Program of Pharmaceutical Sciences Health Sciences Center Federal University of Esp\u00edrito Santo  Avenida Marechal Campos 1468, Bonfim 29047-105 Vit\u00f3ria ES Brazil"},{"name":"Department of Pharmaceutical Sciences Health Sciences Center Federal University of Esp\u00edrito Santo  Avenida Marechal Campos 1468, Bonfim 29047-105 Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginaldo","family":"Bezerra dos Santos","sequence":"additional","affiliation":[{"name":"Department of Chemistry Exact Sciences Center Federal University of Esp\u00edrito Santo  Avenida Fernando Ferrari 514, Goiabeiras 29075-910 Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-6699","authenticated-orcid":false,"given":"Rodrigo Rezende","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Graduate Program of Pharmaceutical Sciences Health Sciences Center Federal University of Esp\u00edrito Santo  Avenida Marechal Campos 1468, Bonfim 29047-105 Vit\u00f3ria ES Brazil"},{"name":"Department of Pharmaceutical Sciences Health Sciences Center Federal University of Esp\u00edrito Santo  Avenida Marechal Campos 1468, Bonfim 29047-105 Vit\u00f3ria ES Brazil"},{"name":"Graduate Program of Chemistry Exact Sciences Center Federal University of Esp\u00edrito Santo  Avenida Fernando Ferrari 514, Goiabeiras 29075-910 Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2017.02.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S232169"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11110677"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051881"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24389"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-019-0139-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/762514"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-10"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i6.1307"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(00)00256-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005963400984"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005969024182"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071751"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2018.03.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i16.1907"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2017-0115"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.07.094"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103133"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111980"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2010.12.010"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17066684"},{"key":"e_1_2_9_23_1","first-page":"19","volume":"4","author":"Rani P.","year":"2013","journal-title":"Int. J. Chem. Pharm. Sci."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00828a048"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1453173"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2009.00793.x"},{"key":"e_1_2_9_28_1","first-page":"1","volume":"1","author":"Yazdan S. K.","year":"2015","journal-title":"Org. Med. Chem. Int. J."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i30.10368"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2006.09.019"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.32604\/biocell.2004.28.031"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1086\/381972"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.11.2702"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.10.024"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103376"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2741\/997"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200105000-00004"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.235.4787.458"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10465"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5359.2121"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306030200"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.115"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.05.004"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200600072"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.08.033"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-013-0520-9"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574892809666140819153902"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.03.002"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(01)00116-X"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.02.052"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/p19800001567"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00325a014"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1081\/SCC-120003144"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/AMR.535-537.2540"},{"key":"e_1_2_9_55_1","unstructured":"CLSI Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard \u2013 10th ed. CLSI document M7-A10. Wayne PA: Clinical and Laboratory Standards Institute 2015 pp. 15-47."},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070776"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1764"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200600592301"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202301066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T08:52:31Z","timestamp":1703667151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202301066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,26]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/cbdv.202301066"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202301066","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,26]]},"assertion":[{"value":"2023-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202301066"}}