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The effects of AGO, PTX and melatonin (MTN) on breast cancer cell viability were investigated, focusing on the role of MT1 receptors. Cell viability and gene expression were analyzed in MCF\u20107 and MDA\u2010MB\u2010231 breast cancer cell experiments. The results show that AGO has cytotoxic effects on breast cancer cells similar to MTN. Combining AGO and MTN with PTX showed synergistic effects in MCF\u20107 cells. The study also reveals differences in the molecular mechanisms of breast cancer between estrogen\u2010positive MCF\u20107 cells and estrogen\u2010negative MDA\u2010MB\u2010231 cells. Combination with AGO and PTX affects apoptosis\u2010associated proteins in both cell types. 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