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Therefore, the novel quinazolinones were synthesized from the reaction of acylated derivatives of 4\u2010hydroxy benzaldehyde with 3\u2010amino\u20102\u2010alkylquinazolin\u20104(<jats:italic>3H<\/jats:italic>)\u2010ones with good yields (85\u201394\u2009%) and their structures were characterized using Fourier\u2010transform Infrared (FT\u2010IR), Nuclear Magnetic Resonance (<jats:sup>1<\/jats:sup>H\u2010NMR, <jats:sup>13<\/jats:sup>C\u2010NMR), and High\u2010Resolution Mass Spectroscopy (HR\u2010MS). As the application of the synthesized compounds, their inhibition properties of the synthesized compounds on \u03b1\u2010Glucosidase (\u03b1\u2010Glu), Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and Carbonic anhydrase I\u2013II (hCA I\u2013II) metabolic enzymes were investigated. All compounds showed inhibition at nanomolar level with the K<jats:sub>i<\/jats:sub> values in the range of 12.73\u00b11.26\u201393.42\u00b19.44\u2005nM for AChE, 8.48\u00b10.92\u201325.84\u00b12.59\u2005nM for BChE, 66.17\u00b15.16\u2013818.06\u00b144.41 for \u03b1\u2010Glu, 2.56\u00b10.26\u201388.23\u00b19.72\u2005nM for hCA I, and 1.68\u00b10.14\u201385.43\u00b17.41\u2005nM for hCA II. Molecular docking study was performed to understand the interactions of the most potent compounds with corresponding enzymes. Also, absorption, distribution, metabolism, excretion, and toxicity (ADME\/T) properties of the compounds were investigated.<\/jats:p>","DOI":"10.1002\/cbdv.202301134","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T20:09:05Z","timestamp":1694462945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Novel Quinazolinone Derivatives: Potential Synthetic Analogs for the Treatment of Glaucoma, Alzheimer's Disease and Diabetes Mellitus"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5532-8802","authenticated-orcid":false,"given":"Feyzi Sinan","family":"Tokal\u0131","sequence":"first","affiliation":[{"name":"Department of Material and Material Processing Technologies, Kars Vocational School Kafkas University  Kars 36100 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science Bartin University  Bartin 74100 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-2043","authenticated-orcid":false,"given":"Burak","family":"Tuzun","sequence":"additional","affiliation":[{"name":"Departmentof Plant and Animal Production, Sivas Technical Sciences Vocational School Sivas Cumhuriyet University  58140 Sivas Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-808X","authenticated-orcid":false,"given":"Ahmet","family":"Karaku\u015f","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science Bartin University  Bartin 74100 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2966-9231","authenticated-orcid":false,"given":"Nastaran","family":"Sadeghian","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science Bartin University  Bartin 74100 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gul\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Atat\u00fcrk University  25240- Erzurum Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103422"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17415993.2011.575943"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA01284A"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0243-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MD00392F"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756360903309412"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201600362"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.03.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/12122621"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000455"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21887"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133266"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116140"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22300"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202202006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202301158"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202200356"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202200370"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202204019"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22031"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.129666"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.4619"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12039-020-01813-1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133647"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127404"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133816"},{"key":"e_1_2_8_27_1","volume":"4","author":"Shafique I.","year":"2022","journal-title":"Res. 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