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The study characterizes the nanoliposomes using the thin\u2010film hydration method and analyzes their size, charge, and polydispersity index. The encapsulation efficiency and drug loading ability of rutin at different concentrations were investigated. The nanoliposomes were found to be stable for up to one month at 4\u2009\u00b0C and showed sustained drug release for up to 24\u2005h. The anti\u2010cancer activity of the rutin\u2010loaded nanoliposomes was found to be concentration\u2010dependent and significantly improved compared to free rutin. PEGylated nanoliposomes with rutin (1.8\u2005mg\/ml) showed the highest encapsulation efficiency and drug loading ability, along with improved selectivity against cancer cells. Overall, the study provides important insights into the potential use of rutin\u2010loaded nanoliposomes for the treatment of colorectal cancer.<\/jats:p>","DOI":"10.1002\/cbdv.202301167","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:24:00Z","timestamp":1696235040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Preparation, Characterization, and Anticancer Activity of PEGylated Nano Liposomal Loaded with Rutin against Human Carcinoma Cells (HT\u201029)"],"prefix":"10.1002","volume":"20","author":[{"given":"Noorin Manhal","family":"Al\u2010Ekaid","sequence":"first","affiliation":[{"name":"Pharmacological and Diagnostic Research Center Faculty of Pharmacy Al-Ahliyya Amman University  Amman 19328 Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Al\u2010Samydai","sequence":"additional","affiliation":[{"name":"Pharmacological and Diagnostic Research Center Faculty of Pharmacy Al-Ahliyya Amman University  Amman 19328 Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Al\u2010deeb","sequence":"additional","affiliation":[{"name":"Pharmacological and Diagnostic Research Center Faculty of Pharmacy Al-Ahliyya Amman University  Amman 19328 Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5916-5879","authenticated-orcid":false,"given":"Hamdi","family":"Nsairat","sequence":"additional","affiliation":[{"name":"Pharmacological and Diagnostic Research Center Faculty of Pharmacy Al-Ahliyya Amman University  Amman 19328 Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Khleifat","sequence":"additional","affiliation":[{"name":"Department of Medical Analysis Faculty of Science Mutah University  Al-Karak 61710 Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walhan","family":"Alshaer","sequence":"additional","affiliation":[{"name":"Cell Therapy Center the University of Jordan  Amman 11942 Jordan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.10.041"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01294-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14274-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012242"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711795328355"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.136438"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA07560G"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2017.07.008"},{"key":"e_1_2_9_9_1","first-page":"27","author":"Odeh F.","year":"2022","journal-title":"Molecules."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA00044J"},{"key":"e_1_2_9_11_1","author":"Imani A.","year":"2020","journal-title":"Phytother Res: PTR"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6904"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300534"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104612"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics8020039"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12645-019-0055-y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17267"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph6111361"},{"issue":"13","key":"e_1_2_9_19_1","first-page":"165","volume":"6","author":"Kutkut M.","year":"2023","journal-title":"J. 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