{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:42Z","timestamp":1753862862051,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Limonium<\/jats:italic>. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two <jats:italic>Limonium<\/jats:italic> species (<jats:italic>L.\u2005pruinosum<\/jats:italic> Kuntze and <jats:italic>L.\u2005tunetanum<\/jats:italic> (Barratte &amp; Bonnet) Maire) in terms of their chemical composition and bioactivity. Chemical profiling showed that the methanolic (MeOH) extracts of both species were the most enriched with total phenolic (TP) and total flavonoid (TF) contents. The TFC were higher in <jats:italic>L.\u2005tunetanum<\/jats:italic> compared to <jats:italic>L.\u2005pruinosum<\/jats:italic>. HPLC\u2010DAD analysis showed that distinctly the gallic acid and L\u2010tyrosine 7\u2010amido\u20104\u2010methylcoumarin were the main compounds for <jats:italic>L.\u2005pruinosum<\/jats:italic> and <jats:italic>L.\u2005tunetanum<\/jats:italic>, respectively. For both <jats:italic>Limonium<\/jats:italic>. Mil species, the MeOH extracts displayed the highest antioxidant with IC<jats:sub>50<\/jats:sub> of 7.7 and 8.4\u2005\u03bcg\/mL for <jats:italic>L.\u2005pruinosum<\/jats:italic> and <jats:italic>L.\u2005tunetanum<\/jats:italic>, respectively. The highest anti\u201015\u2010lipoxygnase activity was recorded in the ethyl acetate (IC<jats:sub>50<\/jats:sub>=14.2\u2005\u03bcg\/mL) and Methanol (IC<jats:sub>50<\/jats:sub>=15.6\u2005\u03bcg\/mL) extracts for <jats:italic>L.\u2005pruinosum<\/jats:italic>. However, for <jats:italic>L.\u2005tunetanum<\/jats:italic> the best activity was recorded for dichloromethane extract (IC<jats:sub>50<\/jats:sub>=10.4\u2005\u03bcg\/mL). <jats:italic>L.\u2005pruinosum<\/jats:italic> extracts displayed the highest cytotoxic activity against MCF\u20107 and HCT\u2010116\u2005cell lines compared to <jats:italic>L.\u2005tunetanum<\/jats:italic> ones. The obtained bioactivity discrepancy between <jats:italic>Limonium<\/jats:italic>. Mill species was discussed in relation to the organic extract chemical richness.<\/jats:p>","DOI":"10.1002\/cbdv.202301177","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T03:29:48Z","timestamp":1699241388000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Analysis of Organic Extracts Bioactivity from Two <i>Limonium<\/i>. Mill Species Growing Wild in Tunisian Salty Marshes"],"prefix":"10.1002","volume":"20","author":[{"given":"Rami","family":"Rahmani","sequence":"first","affiliation":[{"name":"Laboratoire de recherche Biodiversit\u00e9 Mol\u00e9cules et Applications LR22ES02 Institut sup\u00e9rieur de biologie appliqu\u00e9e Universit\u00e9 de Gab\u00e9s  Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6473-6143","authenticated-orcid":false,"given":"Mohamed","family":"Debouba","sequence":"additional","affiliation":[{"name":"Laboratoire de recherche Biodiversit\u00e9 Mol\u00e9cules et Applications LR22ES02 Institut sup\u00e9rieur de biologie appliqu\u00e9e Universit\u00e9 de Gab\u00e9s  Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh Sassi","family":"Aydi","sequence":"additional","affiliation":[{"name":"Laboratory of biodiversity and valorisation of bioresources in arid zones. 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Faculty of Sciences at the University of Gabes, Zrig  6072 Gabes Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2439-5145","authenticated-orcid":false,"given":"Jalloul","family":"Bouajila","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9nie Chimique Universit\u00e9 de Paul Sabatier CNRS, INPT, UPS  France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-57635-6_53"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ecs2.3915"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/su132011282"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1959295"},{"key":"e_1_2_9_5_1","volume":"3","author":"Thirumurugan D.","year":"2018","journal-title":"Second. Metab. 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