{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:12:14Z","timestamp":1790723534036,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The importance of bioactive plant species in the scientific world is increasing day by day. The relationship between health and traditional\u2010modern life, promotes the creation of new value\u2010added natural products. This is the first research to conduct a bioactivity and chemical composition analysis of <jats:italic>Campanula baskilensis<\/jats:italic> species, which belongs to the medicinally important genus <jats:italic>Campanula<\/jats:italic> L (Campanulaceae). The aim of the current study is to quantitatively investigate the phytochemical contents of aerial and root parts of different <jats:italic>C. baskilensis<\/jats:italic> extracts (ethanol, methanol, and water) by LC\u2010MS\/MS and to evaluate their total phenolic and flavonoid contents, antioxidant and enzyme inhibitory activities. Remarkably, LC\u2010MS\/MS results revealed that, high amounts of quinic acid (53.6\u2005mg\/g aerial\u2010MeOH extract), fumaric acid (6.3\u2005mg\/g aerial\u2010H<jats:sub>2<\/jats:sub>O extract, 2.5\u2005mg\/g root\u2010H<jats:sub>2<\/jats:sub>O extract), protocatechuic acid (11.4\u2005mg\/g aerial\u2010H<jats:sub>2<\/jats:sub>O extract), vanillic acid (1.4\u2005mg\/g aerial\u2010EtOH extract), quercetin\u20103\u2010O\u2010rutinoside (rutin) (2.3\u2005mg\/g aerial\u2010EtOH extract), hesperetin 7\u2010rutinoside (hesperidin) (2.0\u2005mg\/g aerial\u2010EtOH extract), kaempferol\u20103\u2010O\u2010rutinoside (nicotiflorin) (5.5\u2005mg\/g aerial\u2010EtOH extract) were detected in the extracts of the species. Considering the bioactivity tests performed on <jats:italic>C. baskilensis<\/jats:italic> extracts, aerial\u2010H<jats:sub>2<\/jats:sub>O extract showed significant activity in all antioxidant assays. However, ethanol extracts of root and aerial parts exhibited the highest activities in all enzyme inhibitory tests.<\/jats:p>","DOI":"10.1002\/cbdv.202301182","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:07:14Z","timestamp":1697530034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Detailed Phytochemical Evaluation of a Locally Endemic Species (<i>Campanula baskilensis<\/i>) by LC\u2010MS\/MS and Its In\u2010Depth Antioxidant and Enzyme Inhibitory Activities"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7227","authenticated-orcid":false,"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Dicle University  Diyarbakir 21280 Turkiye"},{"name":"Dicle University Science and Technology Application and Research Center (DUBTAM)  Diyarbakir 21280 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-2054","authenticated-orcid":false,"given":"O\u011fuz","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Ataturk Faculty of Health Sciences Dicle University  Diyarbakir 21280 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0788-4999","authenticated-orcid":false,"given":"Ebubekir","family":"Izol","sequence":"additional","affiliation":[{"name":"Bee and Natural Products R &amp; D and P &amp; D Application and Research Center Bingol University  Bingol 12000 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-3892","authenticated-orcid":false,"given":"Abbas","family":"Tarhan","sequence":"additional","affiliation":[{"name":"Dicle University Science and Technology Application and Research Center (DUBTAM)  Diyarbakir 21280 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutfi","family":"Behcet","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Arts and Sciences Bingol University  Bingol 12000 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-6484","authenticated-orcid":false,"given":"Gokhan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty Selcuk University  Konya 42130 Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2023.2217264"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.102429"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v15i9.8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10175920"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2018.01.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200227"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2021.104225"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100207"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.02.059"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.112347"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/978-3-540-31051-8_5","volume-title":"Flowering Plants\u22c5Eudicots: Asterales","author":"Lammers T. 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