{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:59:56Z","timestamp":1788469196011,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A novel phenylethanoid, ferruginoside D, together with fourteen known compounds were isolated from the\n                    <jats:italic>Verbascum leiocarpum<\/jats:italic>\n                    for the first time. Chemical structures of isolated compounds were determined by spectroscopic analysis including HR\u2010ESI\u2010MS and NMR spectra. The antioxidant, \u03b1\u2010glucosidase inhibitory properties, and antiproliferative activities against multiple cell lines (A172, C6, HeLa, A2780, SW620, HT29, Beas2B, RPE, and HSF) of the isolated compounds were evaluated\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    . According to the results, iridoids, flavonoids (luteolin and apigenin), and phenylethanoids (poliumoside and isoverbascoside) with strong antiproliferative potential were also found to have cytostatic effects. Furthermore, the investigation revealed that compounds luteolin, poliumoside, verbascoside, isoverbascoside, ferruginoside C, ferruginoside D, and ursolic acid show potent alpha\u2010glucosidase inhibitory activity, while compounds luteolin, verbascoside, and isoverbascoside exhibit substantial antioxidant activity. The new compound (ferruginoside D) was found moderately active against cancer cell lines, with strong alpha\u2010glucosidase inhibitory activity, and moderate antioxidant properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202301200","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T05:30:18Z","timestamp":1698816618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ferruginoside\u2005D: A Novel Phenylethanoid from\n                    <i>Verbascum leiocarpum<\/i>"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-3425","authenticated-orcid":false,"given":"Samed","family":"\u015eim\u015fek","sequence":"first","affiliation":[{"name":"Department of Medical Services and Techniques Cayirli Vocational School Erzincan Binali Yildirim University  24500 Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Ak\u015fit","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Pharmacy Erzincan Binali Yildirim University  25240 Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science Faculty of Medicine Yozgat Bozok University  Yozgat T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekrem","family":"K\u00f6ksal","sequence":"additional","affiliation":[{"name":"Chemistry Department Faculty of Art and Science Erzincan Binali Yildirim University  25240 Erzincan T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"82","author":"Cordeiro M. 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