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In the present work, sixteen alepterolic acid derivatives were synthesized and evaluated for their anticancer activities. Among them, <jats:italic>N<\/jats:italic>\u2010[<jats:italic>m<\/jats:italic>\u2010(trifluoromethoxy)phenyl] alepterolamide displayed comparable activity (IC<jats:sub>50<\/jats:sub>=4.20\u00b10.21\u2005\u03bcM) in MCF\u20107 cells. Moreover, mechanistic investigations indicated this compound was significantly capable of diminishing cell proliferation and viability of MCF\u20107 cells. After treatment with <jats:italic>N<\/jats:italic>\u2010[<jats:italic>m<\/jats:italic>\u2010(trifluoromethoxy)phenyl] alepterolamide, a significant increase in cleaved caspase\u20109, cleaved caspase\u20103, cleaved poly (ADP\u2010ribose) polymerase (PARP) and Bax\/Bcl2 ratio were observed in MCF\u20107 cells, leading to caspase\u2010dependent apoptotic pathways. Further studies showed this compound promoted cellular apoptosis and inhibited migration in MCF\u20107 cells <jats:italic>via<\/jats:italic> modulation of the Akt\/p70<jats:sup>S6K<\/jats:sup> signaling pathway. All these results revealed the potential of <jats:italic>N<\/jats:italic>\u2010[<jats:italic>m<\/jats:italic>\u2010(trifluoromethoxy)phenyl] alepterolamide as an appealing therapeutic drug candidate for breast cancer.<\/jats:p>","DOI":"10.1002\/cbdv.202301248","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T02:17:38Z","timestamp":1695435458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of an Alepterolic Acid Derivative as a Potent Anti\u2010Breast\u2010Cancer Agent via Inhibition of the Akt\/p70<sup>S6K<\/sup> Signaling Pathway"],"prefix":"10.1002","volume":"21","author":[{"given":"Nina","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering Anhui University of Technology, Ma'anshan  Anhui 243002 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences Shanghai Normal University  Shanghai 201418 P.R. 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