{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:29:00Z","timestamp":1779895740371,"version":"3.53.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Allium hookeri<\/jats:italic> (F: Liliaceae), an indigenous plant of Manipur, India, is traditionally used to treat various diseases and disorders like diabetes, hypertension, and stomach ache. In our previous study, the methanol extract of the plant showed significant antidiabetic potential in rats. In the present study, we evaluated the antidiabetic potential of a flavonoid compound named MEA isolated from the methanolic leaf extract of <jats:italic>A. Hookeri<\/jats:italic> in rats. Additionally, we assessed the compound's mode of action through the molecular docking study. The MEA reduced the blood glucose level from 317\u00b112.8 to 99.4\u00b16.67\u2005mg\/dl after 21\u2005days of treatment. Besides, MEA also restored the body weights and other biochemical parameters including lipid profile significantly compared to the diabetic group (p&lt;0.001). The histoarchitecture of the pancreatic tissues of the MEA treated group was also improved compared to the diabetic group. In the docking study, the compound showed good binding affinity in the active binding site of the two structures of pancreatic beta\u2010cell SUR1 (Sulfonylurea Receptor 1) subunit with CDocker energy \u221231.556\u2005kcal\/mol and \u221239.703\u2005kcal\/mol, respectively. The compound MEA was found to be drug\u2010like with non\u2010carcinogenic, non\u2010mutagenic and non\u2010irritant properties. These findings indicate the antidiabetic potential of MEA, which might act by modulating the pancreatic beta\u2010cell SUR1 subunit present in the K<jats:sub>ATP<\/jats:sub> channel. Hence, the MEA would be a promising lead molecule to develop new antidiabetic drug candidates of the future.<\/jats:p>","DOI":"10.1002\/cbdv.202301299","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T12:08:15Z","timestamp":1701691695000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>In Vivo<\/i> and <i>in Silico<\/i> Based Evaluation of Antidiabetic Potential of an Isolated Flavonoid from <i>Allium hookeri<\/i> in Type 2 Diabetic Rat Model"],"prefix":"10.1002","volume":"21","author":[{"given":"Khumanthem Deepak","family":"Singh","sequence":"first","affiliation":[{"name":"Escent Institute of Pharmaceutical Sciences and Research  Imphal 795140 Manipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipak","family":"Chetia","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Faculty of Science and Engineering Dibrugarh University  Dibrugarh 786004 Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelutpal","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Faculty of Science and Engineering Dibrugarh University  Dibrugarh 786004 Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskarjyoti","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Royal School of Bio-Sciences Royal Global University  Guwahati 781035 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8172-6633","authenticated-orcid":false,"given":"Mithun","family":"Rudrapal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Biotechnology and Pharmaceutical Sciences Vignan's Foundation for Science Technology &amp; Research (Deemed to be University)  Guntur 522213 Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01656-8"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i4.598"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_10_4_1","first-page":"632","volume-title":"Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia","author":"Powers A. 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