{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:49:18Z","timestamp":1787590158481,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Boswellia serrata<\/jats:italic>\n                    Roxb. Ex Colebr is a popular medicinal plant used traditionally in herbal medicinal preparations to treat a variety of diseases. The purpose of the present investigation was to investigate the anti\u2010hemorrhoidal property of the bark extract of\n                    <jats:italic>B.\u2005serrata<\/jats:italic>\n                    (BS). For this, the sequential Soxhlet extraction method was carried out by using different solvents such as hexane, chloroform, and methanol. After the extraction, the obtained dry extracts were tested for quantitative determinations such as total alkaloid content (TAC), total flavonoid content (TFC), total phenol content (TPC), and total tannin content (TTC) for all the extracts. Moreover,\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    antioxidant activity was measured using 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) free radical scavenging activity and scavenging activity against 2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid (ABTS). Methanolic bark extract showed the highest TPC (67.10\u00b11.83), TFC (372.73\u00b14.45), TAC (9.732\u00b11.06), and TTC (48.932\u00b11.82), as well as the antioxidant assays DPPH (IC50=9.88\u2005\u03bcg\/ml) and ABTS (IC50=15.09\u2005\u03bcg\/ml). In this study, both LC\u2013MS and GC\u2013MS were performed to identify the chemical composition of all the extracts. Consequently, 19\u2005compounds were identified by GC\u2013MS and 27\u2005compounds were identified by LC\u2013MS analysis. The identified phytoconstituent(s) that could potentially interact with the target protein cyclooxygenase\u20102 (COX\u20102) (PDB: 4RRW) using molecular dynamics simulation and\n                    <jats:italic>in silico<\/jats:italic>\n                    docking were studied. Three compounds that have passed in drug\u2010likeness and ADME\u2010Tox properties are having more docking score than the standard. In this study, camptothecin, justicidin B, and taxiphyllin are identified as potential lead compounds with anti\u2010hemorrhoidal properties and may be helpful in the process of drug development and discovery of novel drugs. Hence, these results demonstrate that BS is a good source of pharmacologically active components with potential applications against hemorrhoidal disease.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202301416","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T13:59:53Z","timestamp":1702303193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>In Silico<\/i>\n                    Exploration of Potential Phytoconstituents from the Bark Extract of\n                    <i>Boswellia serrata<\/i>\n                    for Hemorrhoidal Disease: Molecular Docking and Molecular Dynamics Analysis**"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1967-2375","authenticated-orcid":false,"given":"Harshawardhan","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Pharmacy Indira Gandhi National Tribal University  484887 Amarkantak Anuppur District, Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7726-1941","authenticated-orcid":false,"given":"Aryan","family":"Maurya","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Indira Gandhi National Tribal University  484887 Amarkantak Anuppur District, Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2783-8036","authenticated-orcid":false,"given":"Hemant","family":"Kumar Raidas","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Indira Gandhi National Tribal University  484887 Amarkantak Anuppur District, Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1992-2916","authenticated-orcid":false,"given":"Bholeshankar","family":"Koram","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Indira Gandhi National Tribal University  484887 Amarkantak Anuppur District, Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0416-8970","authenticated-orcid":false,"given":"Rohit","family":"Kumar Goswami","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Indira Gandhi National Tribal University  484887 Amarkantak Anuppur District, Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-8824","authenticated-orcid":false,"given":"Vivek","family":"Singh Rajpoot","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Indira Gandhi National Tribal University  484887 Amarkantak Anuppur District, Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-2541","authenticated-orcid":false,"given":"Sulekha","family":"Khute","sequence":"additional","affiliation":[{"name":"University Institute of Pharmacy Pt. Ravishankar Shukla University  492010 Raipur Chhattisgarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8060-1591","authenticated-orcid":false,"given":"Paranthaman","family":"Subash","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Sri Shanmugha College of Pharmacy  637304 Sankari Salem District, Tamilnadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-489X","authenticated-orcid":false,"given":"Subhash","family":"Chandra Mandal","sequence":"additional","affiliation":[{"name":"Pharmacognosy &amp; Phytotherapy Research Laboratory Division of Pharmacognosy Department of Pharmaceutical Technology Faculty of Engineering &amp; Technology Jadavpur University  700032 Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7446-5048","authenticated-orcid":false,"given":"Subham","family":"Saha","sequence":"additional","affiliation":[{"name":"Pharmacognosy &amp; Phytotherapy Research Laboratory Division of Pharmacognosy Department of Pharmaceutical Technology Faculty of Engineering &amp; Technology Jadavpur University  700032 Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8359-7380","authenticated-orcid":false,"given":"Srinivasa","family":"Rao Kareti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Indira Gandhi National Tribal University  484887 Amarkantak Anuppur District, Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10061135"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2129-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2023.e01593"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2021.101285"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.93507"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.06.053"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2021.100172"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11112129"},{"key":"e_1_2_9_9_1","first-page":"31","volume-title":"Boswellia serrata","author":"Castilho A. 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