{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:01:28Z","timestamp":1774432888036,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Short Title: Benzimidazoisoquinoline derivatives as potent antifibrotics Hepatic fibrosis is a pathological condition of liver disease with an increasing number of cases worldwide. Therapeutic strategies are warranted to target the activated hepatic stellate cells (HSCs), the collagen\u2010producing cells, an effective strategy for controlling the disease progression. Benzimidazoisoquinoline derivatives were synthesized as hybrid molecules by the combination of benzimidazoles and isoquinolines to evaluate their anti\u2010fibrotic potential using an in\u2010vitro and in\u2010vivo model of hepatic fibrosis. A small library of benzimidazoisoquinoline derivatives (<jats:bold>1<\/jats:bold>\u2013<jats:bold>17<\/jats:bold> and <jats:bold>18<\/jats:bold>\u2013<jats:bold>21<\/jats:bold>) was synthesized from 2\u2010aryl benzimidazole and acetylene functionalities through C\u2212H and N\u2212H activation. Compounds (<jats:bold>10<\/jats:bold> and its recently synthesized derivatives <jats:bold>18<\/jats:bold>\u2013<jats:bold>21<\/jats:bold>) depicted a significant decrease in PDGF\u2010BB and\/or TGF\u03b2\u2010induced proliferation (1.7\u20131.9 \u2010fold), migration (3.5\u20135.0 \u2010fold), and fibrosis\u2010related gene expressions in HSCs. These compounds could revert the hepatic damage caused by chronic exposure to hepatotoxicants, ethanol, and\/or carbon tetrachloride as evident from the histological, biochemical, and molecular analysis. Anti\u2010fibrotic effect of the compounds was supported by the decrease in the malondialdehyde level, collagen deposition, and gene expression levels of fibrosis\u2010related markers such as \u03b1\u2010SMA, COL1\u03b11, PDGFR\u03b2, and TGFRII\u03b2 in the preclinical models of hepatic fibrosis. In conclusion, the synthesized benzimidazoisoquinoline derivatives (compounds <jats:bold>18<\/jats:bold>, <jats:bold>19<\/jats:bold>, <jats:bold>20<\/jats:bold>, and <jats:bold>21<\/jats:bold>) possess anti\u2010fibrotic therapeutic potential against liver fibrosis.<\/jats:p>","DOI":"10.1002\/cbdv.202301429","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T07:39:43Z","timestamp":1705304383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic Potential of Benzimidazoisoquinoline Derivatives in Alleviating Murine Hepatic Fibrosis"],"prefix":"10.1002","volume":"21","author":[{"given":"Sowmya","family":"Mekala","sequence":"first","affiliation":[{"name":"Department of Applied Biology CSIR-Indian Institute of Chemical Technology  Uppal Road Hyderabad TS-500 007 INDIA"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 INDIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genji","family":"Sukumar","sequence":"additional","affiliation":[{"name":"Department of Organic Synthesis and Process Chemistry CSIR-Indian Institute of Chemical Technology  Uppal Road Hyderabad TS-500007 INDIA"},{"name":"Department of Chemistry Adikavi Nannaya University  Rajamahendravaram AP-533 296 INDIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Applied Biology CSIR-Indian Institute of Chemical Technology  Uppal Road Hyderabad TS-500 007 INDIA"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 INDIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramasatyaveni","family":"Geesala","sequence":"additional","affiliation":[{"name":"Department of Applied Biology CSIR-Indian Institute of Chemical Technology  Uppal Road Hyderabad TS-500 007 INDIA"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 INDIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jupally","family":"Prashanth","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 INDIA"},{"name":"Centre for X-ray Crystallography Department of Analytical &amp; Structural Chemistry CSIR-Indian Institute of Chemical Technology  Uppal Road Hyderabad TS-500 007 INDIA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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