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The structures of the synthesized compounds were characterised by common spectroscopic and analytical methods. Biguanide compounds showed considerably lower inhibitory activity compared to the reference drugs donepezil and galantamine. On the other hand, complexation of the biguanide compounds with Cu(II) resulted in dramatic increase in the inhibitory activity. The Cu(II) complexes showed AChE inhibitory activity with the IC<jats:sub>50<\/jats:sub> values of 21.29\u00b10.95\u201382.53\u00b10.20\u2005\u03bcM and those values are comparable to that of donepezil (IC<jats:sub>50<\/jats:sub>: 18.54\u00b11.03\u2005\u03bcM). The synthesised compounds were also screened for their antimicrobial activity towards gram positive (+) and gram negative (\u2212) bacteria. Compounds (12.50\u2005mg\/mL) showed important antibacterial properties with inhibition zones of 8\u201328\u2005mm diameter against gram\u2010positive and gram\u2010negative microorganisms. Compounds A03 and A08 exhibited more antimicrobial properties towards <jats:italic>E. coli<\/jats:italic> than standard antibiotics amikacin and gentamicin.<\/jats:p>","DOI":"10.1002\/cbdv.202301434","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T14:55:55Z","timestamp":1702652155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Series of Biguanide Ligands and Their Cu(II) Complexes: Cholinesterase Inhibitory and Antimicrobial Properties"],"prefix":"10.1002","volume":"21","author":[{"given":"Julide Nacaroglu","family":"Ball\u0131","sequence":"first","affiliation":[{"name":"Science Faculty Chemistry Department Kahramanmaras Sutcu Imam University  Avsar Campus Kahramanmaras TURKEY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozge","family":"Gungor","sequence":"additional","affiliation":[{"name":"Science Faculty Chemistry Department Kahramanmaras Sutcu Imam University  Avsar Campus Kahramanmaras TURKEY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet","family":"Kose","sequence":"additional","affiliation":[{"name":"Science Faculty Chemistry Department Kahramanmaras Sutcu Imam University  Avsar Campus Kahramanmaras TURKEY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113378"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113726"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"E. 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