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In this sense, recent research highlights the potential of compounds of natural origin in treating and preventing different types of cancer. <jats:italic>Myrciaria glazioviana<\/jats:italic> is a Brazilian native species belonging to the Myrtaceae family, which has previously described biological activities such as antimicrobial, anti\u2010inflammatory, and antioxidant properties. This study aims to evaluate the anticancer activity of the dichloromethane extract (MGD) and ethyl acetate extract (MGA) of <jats:italic>M. glazioviana<\/jats:italic> leaves against human cervical cancer cell line (HeLa), as well as to identify their bioactive compounds. Using HPLC\u2010HRESIMS technique, ten compounds were characterized in both samples: quinic acid, ellagic acid, Tri\u2010O\u2010methyl ellagic acid, two derivatives of Tetra\u2010O\u2010methyl flavellagic acid, quercetrin, Di\u2010O\u2010methyl ellagic acid, and three derivatives of pentamethyl coruleoellagic acid. Through MTT assays using HeLa cells and NIH\/3T3 cells, it was observed that MGD and MGA were selective against tumor cells, with IC<jats:sub>50<\/jats:sub> values of 24.31 and 12.62\u2005\u03bcg\/mL, respectively. The samples induced the tumor cell death by apoptosis, as evidenced by the activation of caspases 3\/7, cell shrinkage, and pyknotic nuclei. Both samples were also able to inhibit the migration of HeLa cells after 24\u2005hours of treatment, indicating a potential antimetastatic effect. Therefore, the present research highlights the antiproliferative and antimigratory potential of this species against HeLa cells.<\/jats:p>","DOI":"10.1002\/cbdv.202301467","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T18:43:01Z","timestamp":1710268981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the Antiproliferative Potential of Yellow Jaboticaba (<i>Myrciaria glazioviana)<\/i> Extracts Against Human Cervical Cancer (HeLa cells line) and the Analysis of Their Chemical Composition by HPLC\u2010HRESIMS"],"prefix":"10.1002","volume":"21","author":[{"given":"Mariana","family":"Toledo Martins Pereira","sequence":"first","affiliation":[{"name":"Graduate Program in Science and Biotechnology Institute of Biology, UFF  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Research Laboratory of Natural Products and Bioactive Molecules Nova Friburgo Health Institute, UFF  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Sardou Charret","sequence":"additional","affiliation":[{"name":"Graduate Program in Science and Biotechnology Institute of Biology, UFF  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Research Laboratory of Natural Products and Bioactive Molecules Nova Friburgo Health Institute, UFF  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Freimann Wermelinger","sequence":"additional","affiliation":[{"name":"Multiuser Biomedical Research Laboratory Nova Friburgo Health Institute, UFF  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalya","family":"Soares Ribeiro Nogueira","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Sciences Center for Exact Sciences and Technology, UENF  Campos dos Goytacazes Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Kaufmann Robbs","sequence":"additional","affiliation":[{"name":"Multiuser Biomedical Research Laboratory Nova Friburgo Health Institute, UFF  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Carvalho Castiglione","sequence":"additional","affiliation":[{"name":"Laboratory for Clinical and Experimental Research on Vascular Biology (BioVasc) Biomedical Center State University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Loureiro Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Laboratory for Cellular and Molecular Pharmacology Biomedical Center State University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Luiz","family":"Dantas Machado","sequence":"additional","affiliation":[{"name":"Graduate Program in Science and Biotechnology Institute of Biology, UFF  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Department of Microbiology and Parasitology Institute of Biology, UFF  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo Jos\u00e9","family":"Curcino Vieira","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Sciences Center for Exact Sciences and Technology, UENF  Campos dos Goytacazes Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Silva","family":"Abreu","sequence":"additional","affiliation":[{"name":"Natural Products Chemistry Laboratory Institute of Chemistry, UFF  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4234-4843","authenticated-orcid":false,"given":"Vinicius","family":"D'Avila Bitencourt Pascoal","sequence":"additional","affiliation":[{"name":"Graduate Program in Science and Biotechnology Institute of Biology, UFF  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Research Laboratory of Natural Products and Bioactive Molecules Nova Friburgo Health Institute, UFF  Nova Friburgo Rio de Janeiro Brazil"},{"name":"Multiuser Biomedical Research Laboratory Nova Friburgo Health Institute, UFF  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aislan Cristina","family":"Rheder Fagundes Pascoal","sequence":"additional","affiliation":[{"name":"Graduate Program in Science and Biotechnology Institute of Biology, UFF  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Research Laboratory of Natural Products and Bioactive Molecules Nova Friburgo Health Institute, UFF  Nova Friburgo Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"INCA \u2013 Instituto Nacional de C\u00e2ncer. 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