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Their planar and relative structures were determined by an analysis of 1D and 2D nuclear magnetic resonance (NMR) as well as high resolution electrospray ionization mass spectroscopy (HR\u2010ESI\u2010MS) data. The absolute configuration of <jats:bold>1<\/jats:bold> was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Penicitrinol B (<jats:bold>6<\/jats:bold>) significantly inhibited RSL3\u2010induced ferroptosis (EC<jats:sub>50<\/jats:sub>=2.0\u2005\u03bcM) by reducing lipid peroxidation and heme oxygenase 1 (HMOX1) expression. Under the concentration of 10\u2005\u03bcM, penicitrinol A (<jats:bold>7<\/jats:bold>) was able to inhibit cuproptosis with the cell viabilities of 68.2\u2009% compared to the negative control (copper and elesclomol) with the cell viabilities of 14.8\u2009%.<\/jats:p>","DOI":"10.1002\/cbdv.202301507","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T14:25:11Z","timestamp":1697552711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chemical Constituents of the Deep\u2010sea Gammarid Shrimp\u2010Derived Fungus <i>Penicillium citrinum<\/i> XIA\u201016"],"prefix":"10.1002","volume":"20","author":[{"given":"Hao\u2010Yu","family":"Yu","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Wenhua Road 103 Shenyang 110016 China"},{"name":"Key Laboratory of Marine Genetic Resources Third Institute of Oceanography, Ministry of Natural Resources  184 Daxue Road Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"The School of Basic Medical Sciences Fujian Medical University  1 Xueyuan Road Fuzhou 350122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Wenhua Road 103 Shenyang 110016 China"},{"name":"Key Laboratory of Marine Genetic Resources Third Institute of Oceanography, Ministry of Natural Resources  184 Daxue Road Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Biao","family":"Zou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Genetic Resources Third Institute of Oceanography, Ministry of Natural Resources  184 Daxue Road Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Jia","family":"Hao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Genetic Resources Third Institute of Oceanography, Ministry of Natural Resources  184 Daxue Road Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Min","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Genetic Resources Third Institute of Oceanography, Ministry of Natural Resources  184 Daxue Road Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Sheng","family":"Li","sequence":"additional","affiliation":[{"name":"The School of Basic Medical Sciences Fujian Medical University  1 Xueyuan Road Fuzhou 350122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u2010Li","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Wenhua Road 103 Shenyang 110016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4967-0844","authenticated-orcid":false,"given":"Xian\u2010Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Genetic Resources Third Institute of Oceanography, Ministry of Natural Resources  184 Daxue Road Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.15347"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12488"},{"key":"e_1_2_9_3_1","volume":"289","author":"Hopkins M. 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