{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:11:01Z","timestamp":1790863861199,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immortelle, a revered Mediterranean medicinal plant, is celebrated for its potent essential oil renowned in the cosmetic industry for its skin\u2010enhancing properties. Yet, immortelle hydrosol, an often\u2010overlooked byproduct, holds promise in cosmetics due to its compatibility with polar active ingredients. This study investigates the chemical composition of immortelle hydrosol by employing liquid\u2010liquid extraction (LLE) to transfer volatile organic components into nonpolar solvents. Four solvents \u2013 chloroform, dichloromethane, hexane, and benzene \u2013 were assessed through ten consecutive extractions from industrially produced immortelle hydrosol. Quantification was achieved using GC analysis with tetradecane as an internal standard. Chloroform emerged as the most efficient solvent, yielding 2447.0\u2005mg\/L of volatile compounds, surpassing dichloromethane, hexane, and benzene. Key compounds in immortelle hydrosol included 3\u2010pentanone, 2\u2010methyl\u20101\u2010butanol, and \u03b3\u2010terpineol. Importantly, the study revealed that a portion of essential oil compounds persists in the hydrosol even after ten LLE cycles, with optimal results achievable in five extractions (~92\u2009% in most cases).<\/jats:p>","DOI":"10.1002\/cbdv.202301528","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T11:55:46Z","timestamp":1703073346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multiple liquid\u2010liquid extraction of dissolved compounds in immortelle hydrosol with four different solvents"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6905-7240","authenticated-orcid":false,"given":"Andreja","family":"Komneni\u0107","sequence":"first","affiliation":[{"name":"Department of Field and Vegetable Crops, Biotechnical Faculty in Podgorica University of Montenegro  Mihaila Lali\u0107a 15 81000 Podgorica Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorica","family":"Lazarevi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medicinal Plants Research \u201cDr. Josif Pan\u010di\u0107\u201d  Tadeu\u0161a Ko\u0161\u0107u\u0161ka 1 11000 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Jovovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Field and Vegetable Crops, Biotechnical Faculty in Podgorica University of Montenegro  Mihaila Lali\u0107a 15 81000 Podgorica Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"\u0160avikin","sequence":"additional","affiliation":[{"name":"Institute for Medicinal Plants Research \u201cDr. Josif Pan\u010di\u0107\u201d  Tadeu\u0161a Ko\u0161\u0107u\u0161ka 1 11000 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Pljevljaku\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medicinal Plants Research \u201cDr. Josif Pan\u010di\u0107\u201d  Tadeu\u0161a Ko\u0161\u0107u\u0161ka 1 11000 Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03010-13"},{"key":"e_1_2_10_2_1","unstructured":"P. Tannous R. Juliani M. Wang J. Simon Water balance in hydrosol production via steam distillation: case study using lavandin (Lavandula x intermedia). New use agriculture and natural plant products. Technical Report. 14\u2005pp. Technical Report submitted to the National Organic Consumer Association2004."},{"key":"e_1_2_10_3_1","first-page":"157","volume-title":"Aromatherapy for Health Professionals","author":"Price S.","year":"2007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2009.10643705"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5958\/0975-6892.2014.00002.1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112033"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics5010011"},{"key":"e_1_2_10_8_1","unstructured":"Y. Milou K. Fontes C. 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