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LC\/MS\u2010MS was used to perform phytochemical analyses on a 70\u2009% methanol extract of the plant\u2018s aerial parts. In vivo, linear incision and circular excision models were used to evaluate the wound healing activity. For anti\u2010inflammatory effect, in\u2005vivo acetic acid capillary permeability assay and in\u2005vitro Interleukin\u20051, Interleukin\u20056, and Interferon \u0263 levels in LPS\u2010induced FR skin fibroblast cell line were also evaluated. The extract significantly improved wound healing in experimental models, with tensile strength values of 27.8\u2009% and a contraction value of 35.09\u2009%. Histopathological examinations, hydroxyproline estimation, hyaluronidase, collagenase, and elastase enzyme inhibitory assays confirmed wound healing potential. Inflammatory cytokines were significantly inhibited in the LPS\u2010induced FR cell line, with the highest effect seen on IL\u20106 (34.5\u00b12.12\u2005pg\/mL). This study offered the first concrete proof that <jats:italic>H. canum<\/jats:italic> can be used to treat wounds by suggesting that the myricetin and quinic acid content identified by LCMS\u2010MS analysis may be accountable for the effect of <jats:italic>H. canum<\/jats:italic> on wound contraction and hydroxyproline production.<\/jats:p>","DOI":"10.1002\/cbdv.202301529","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T10:34:32Z","timestamp":1699871672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Wound\u2010Healing Potential of the Endemic Plant <i>Helianthemum canum<\/i> (L.) 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