{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:49Z","timestamp":1786977349735,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Compound\n                    <jats:bold>3<\/jats:bold>\n                    , a trimeric anthranilic acid peptide, and another three metabolites were isolated from an organic extract from the culture medium of\n                    <jats:italic>Malbranchea flocciformis<\/jats:italic>\n                    ATCC 34530. The chemical structure proposed previously for\n                    <jats:bold>3<\/jats:bold>\n                    was unequivocally assigned via synthesis and X\u2010ray diffraction analysis. Tripeptide\n                    <jats:bold>3<\/jats:bold>\n                    showed insulinotropic properties by decreasing the postprandial peak in healthy and hyperglycemic mice. It also increased glucose\u2010induced insulin secretion in INS\u20101E at 5\u2005\u03bcM, specifically at higher glucose concentrations. These results revealed that\n                    <jats:bold>3<\/jats:bold>\n                    might act as an insulin sensitizer and a non\u2010classical insulin secretagogue. Altogether, these findings are in harmony with the\n                    <jats:italic>in\u2005vivo<\/jats:italic>\n                    oral glucose tolerance test and acute oral hypoglycemic assay. Finally, the chemical composition of the extract was established by the Global Natural Products Social Molecular Network platform. Phylogenetic analysis using the internal transcribed spacer region revealed that\n                    <jats:italic>M.\u2005flocciformis<\/jats:italic>\n                    ATCC 34530 is related to the\n                    <jats:italic>Malbrancheaceae<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202301602","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T22:19:27Z","timestamp":1702678767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antidiabetic Potential of a Trimeric Anthranilic Acid Peptide Isolated from\n                    <i>Malbranchea flocciformis<\/i>"],"prefix":"10.1002","volume":"21","author":[{"given":"Daniela","family":"Rebollar\u2010Ramos","sequence":"first","affiliation":[{"name":"Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico 04510 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Ovalle\u2010Magallanes","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico 04510 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huzefa A.","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of North Carolina at Greensboro  Greensboro NC-27412 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Jacome\u2010Rebollo","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico 04510 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico 04510 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tovar\u2010Palacio","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Nutrici\u00f3n Instituto Nacional Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Ciudad de M\u00e9xico 14080 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia G.","family":"Noriega","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda de la Nutrici\u00f3n Instituto Nacional Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Ciudad de M\u00e9xico 14080 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Madariaga\u2010Maz\u00f3n","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Unidad M\u00e9rida and f Instituto de Investigaciones en Matem\u00e1ticas Aplicadas y en Sistemas Unidad M\u00e9rida Universidad Nacional Aut\u00f3noma de M\u00e9xico  M\u00e9rida Yucat\u00e1n M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-2768","authenticated-orcid":false,"given":"Rachel","family":"Mata","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico 04510 M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"International Diabetes Federation. 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