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The compound causes cell cycle arrest at distinct phases in different cell lines: G1\/S arrest in RT112 cells, G2\/M arrest in HTB9 cells, and S phase arrest in HT1376 cells. Furthermore, herniarin induces caspase\u2010mediated apoptosis in various cell lines and simultaneously modulates protein levels of apoptotic and anti\u2010apoptotic proteins, indicating its potential as a therapeutic agent. Herniarin's influence also extends to Erk signaling, a crucial pathway that regulates cell growth and differentiation. In conclusion, this study reveals herniarin\u2018s potential as a versatile agent in the treatment of bladder cancer.<\/jats:p>","DOI":"10.1002\/cbdv.202301645","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T14:07:12Z","timestamp":1705586832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Herniarin on Cell Viability, Cell Cycle, and Erk Protein Levels in Different Stages of Bladder Cancer Cells"],"prefix":"10.1002","volume":"21","author":[{"given":"Tuba Ozdemir","family":"Sanci","sequence":"first","affiliation":[{"name":"Department of Histology and Embriyology Faculty of Medicine Ankara Yildirim Beyazit University  Ankara T\u00fcrkiye"},{"name":"Ankara Yildirim Beyazit University Yenimahalle Training and Research Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Terzi","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Faculty of Medicine Ankara Yildirim Beyazit University  Ankara T\u00fcrkiye"},{"name":"Ankara Yildirim Beyazit University Yenimahalle Training and Research Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyza Ecem","family":"Oz Bedir","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Faculty of Medicine Ankara Yildirim Beyazit University  Ankara T\u00fcrkiye"},{"name":"Ankara Yildirim Beyazit University Yenimahalle Training and Research Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Gumustas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Agri \u0130brahim Cecen University  Agri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Kilis 7 Aralik University  Kilis T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-019-00077-9"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103095"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57080749"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.17140\/UAOJ-2-115"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17598"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.11.012"},{"key":"e_1_2_9_7_1","first-page":"1213","volume":"14","author":"Clark P. 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